Western Blot (WB)
(TTK Antibody (N-term) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the TTK antibody detected the TTK protein (arrow).)
Rabbit TTK Polyclonal Antibody | anti-TTK antibody
TTK Antibody (N-term)
Western Blot (WB)
(TTK Antibody (N-term) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the TTK antibody detected the TTK protein (arrow).)
Western Blot (WB)
(TTK Antibody (N-term) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the TTK antibody detected the TTK protein (arrow).)
the ability to phosphorylate tyrosine, serine and threonine.
Associated with cell proliferation, this protein is essential for
chromosome alignment at the centromere during mitosis and is
required for centrosome duplication. It has been found to be a
critical mitotic checkpoint protein for accurate segregation of
chromosomes during mitosis. Tumorigenesis may occur when this
protein fails to degrade and produces excess centrosomes resulting
in aberrant mitotic spindles. Alternative splicing results in
multiple transcript variants.
Maciejowski, J., et al. J. Cell Biol. 190(1):89-100(2010)
Santaguida, S., et al. J. Cell Biol. 190(1):73-87(2010)
Hewitt, L., et al. J. Cell Biol. 190(1):25-34(2010)
Lan, W., et al. J. Cell Biol. 190(1):21-24(2010)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Uniprot Description
TTK: a dual-specificity protein kinase orthologous to the yeast monopolar spindle (Mps1) kinase that is required for spindle pole duplication and the spindle checkpoint but not for centrosome duplication. Localized to centrosomes, kinetochores and nuclear pores. Its enzymatic activity is required for the recruitment of Mad1, Mad2, Bub1 and Bub3 to the kinetochore. Mps1 mRNA levels change little throughout the cell cycle, but its protein expression varies during the cell cycle. Overexpression arrests cells in metaphase by activating the checkpoint.
Protein type: EC 2.7.12.1; Kinase, protein; Cancer Testis Antigen (CTA); Protein kinase, dual-specificity (non-receptor); Protein kinase, Other; Other group; TTK family
Chromosomal Location of Human Ortholog: 6q14.1
Cellular Component: membrane; spindle
Molecular Function: protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity; ATP binding
Biological Process: mitotic spindle organization and biogenesis; peptidyl-tyrosine phosphorylation; mitotic cell cycle spindle assembly checkpoint; positive regulation of cell proliferation; spindle organization and biogenesis; chromosome separation
Research Articles on TTK
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Product Notes
The TTK ttk (Catalog #AAA9208171) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 6-35. The TTK Antibody (N-term) reacts with Human (Predicted Reactivity: Monkey) and may cross-react with other species as described in the data sheet. AAA Biotech's TTK can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the TTK ttk for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TTK, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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