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Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using TTI1 Polyclonal Antibody at dilution 1:40)

Rabbit anti-Human, Mouse TTI1 Polyclonal Antibody | anti-TTI1 antibody

TTI1 Polyclonal Antibody

Gene Names
TTI1; smg-10; KIAA0406
Reactivity
Human, Mouse
Applications
ELISA, Immunohistochemistry
Purity
Antigen Affinity Purification
Synonyms
TTI1; Polyclonal Antibody; TTI1 Polyclonal Antibody; smg-10; KIAA0406; anti-TTI1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Affinity Purification
Concentration
2.7mg/ml (varies by lot)
Sequence Length
1089
Applicable Applications for anti-TTI1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes
ELISA: 1:2000-10000
IHC: 1:30-150
Immunogen
Synthetic peptide of human TTI1
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-85604 / sc-85605
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using TTI1 Polyclonal Antibody at dilution 1:40)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using TTI1 Polyclonal Antibody at dilution 1:40)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TTI1 Polyclonal Antibody at dilution 1:40)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TTI1 Polyclonal Antibody at dilution 1:40)
Related Product Information for anti-TTI1 antibody
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
122,069 Da
NCBI Official Full Name
TELO2-interacting protein 1 homolog
NCBI Official Synonym Full Names
TELO2 interacting protein 1
NCBI Official Symbol
TTI1
NCBI Official Synonym Symbols
smg-10; KIAA0406
NCBI Protein Information
TELO2-interacting protein 1 homolog
UniProt Protein Name
TELO2-interacting protein 1 homolog
Protein Family
UniProt Gene Name
TTI1
UniProt Synonym Gene Names
KIAA0406; SMG10
UniProt Entry Name
TTI1_HUMAN

Uniprot Description

TTI1: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. Belongs to the tti1 family.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 20q11.23

Cellular Component: cytoplasm; TORC2 complex

Molecular Function: protein binding

Biological Process: regulation of TOR signaling pathway

Research Articles on TTI1

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Product Notes

The TTI1 tti1 (Catalog #AAA2542888) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TTI1 Polyclonal Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's TTI1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). ELISA: 1:2000-10000 IHC: 1:30-150. Researchers should empirically determine the suitability of the TTI1 tti1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TTI1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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