Goat TSPYL2 / DENTT Polyclonal Antibody | anti-TSPYL2 antibody

Goat Polyclonal to Human TSPYL2 / DENTT

Cat. Num. AAA244346

• Gene Names: TSPYL2; CDA1; CTCL; NP79; TSPX; CINAP; DENTT; SE204; HRIHFB2216
• Reactivity: Gibbon, Gorilla, Human, Monkey
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: TSPYL2 / DENTT; Polyclonal Antibody; Goat Polyclonal to Human TSPYL2 / DENTT; Anti-TSPYL2 / DENTT Antibody (C-Terminus) IHC-plus; TSPYL2; CDA1; CINAP; DENTT; CTCL; CTCL-associated antigen se20-4; Cell division autoantigen 1; HRIHFB2216; Nuclear protein of 79 kDa; NP79; TSPY-like protein 2; SE20-4; SE204; TSPY-like 2; CTCL tumor antigen se20-4; TSPX; Human TSPYL2; anti-TSPYL2 antibody

• Host: Goat
• Reactivity: Gibbon, Gorilla, Human, Monkey
• Clonality: Polyclonal
• Specificity: Human TSPYL2.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 693

• Applicable Applications for anti-TSPYL2 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA (1:8000), IHC-P (5 ug/ml); Usage: Peptide ELISA: antibody detection limit dilution 1:8000. Western blot: Preliminary experiments in Human Testis lysates gave no specific signal but low background (at antibody concentration up to 1 ug/ml).
• Target Species: Human
• Immunogen Description: Synthetic peptide C-PNGWANPGKRGKTG from the C-terminus of human TSPYL2 (NP_071400.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Panda, Dog, Horse (86%).
• Immunogen Type: Synthetic peptide
• Immunogen: TSPYL2 / DENTT antibody was raised against synthetic peptide C-PNGWANPGKRGKTG from the C-terminus of human TSPYL2 (NP_071400.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Panda, Dog, Horse (86%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-TSPYL2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 11545835
• NCBI GeneID: 64061
• NCBI Accession #: NP_071400.1
• NCBI GenBank Nucleotide #: NM_022117.3
• UniProt Accession #: Q9H2G4; O94799; Q96DG7; Q9BZW6
• Molecular Weight: 79,435 Da
• NCBI Official Full Name: testis-specific Y-encoded-like protein 2
• NCBI Official Synonym Full Names: TSPY-like 2
• NCBI Official Symbol: TSPYL2
• NCBI Official Synonym Symbols: CDA1; CTCL; NP79; TSPX; CINAP; DENTT; SE204; HRIHFB2216
• NCBI Protein Information: testis-specific Y-encoded-like protein 2; TSPY-like protein 2; CTCL tumor antigen se20-4; nuclear protein of 79 kDa; cell division autoantigen 1; CTCL-associated antigen se20-4; testis-specific protein Y encoded-like 2; CASK-interacting nucleosome assembly protein; cutaneous T-cell lymphoma-associated antigen se20-4; differentially expressed nucleolar TGF-beta1 target; cutaneous T-cell lymphoma-associated tumor antigen se20-4; differentially-expressed nucleolar TGF-beta1 target protein
• UniProt Protein Name: Testis-specific Y-encoded-like protein 2
• Protein Family: Testis-specific Y-encoded-like protein
• UniProt Gene Name: TSPYL2
• UniProt Synonym Gene Names: CDA1; DENTT; TSPX; TSPY-like protein 2; CTCL-associated antigen se20-4; NP79
• UniProt Entry Name: TSYL2_HUMAN

NCBI Description

This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]

Uniprot Description

TSPYL2: Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. Belongs to the nucleosome assembly protein (NAP) family.

Protein type: Transcription regulation; DNA replication

Chromosomal Location of Human Ortholog: Xp11.2

Cellular Component: nucleoplasm; centrosome; cytoplasm; plasma membrane; nucleolus; nucleus

Molecular Function: rDNA binding

Biological Process: transcription, DNA-dependent; unfolded protein response; regulation of signal transduction; chromatin modification; cell cycle; negative regulation of cell cycle; nucleosome assembly; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; regulation of transcription, DNA-dependent; negative regulation of DNA replication; negative regulation of cell growth; regulation of protein kinase activity