Rabbit anti-Human TSNAX Polyclonal Antibody | anti-TSNAX antibody

TSNAX, NT (TSNAX, TRAX, Translin-associated protein X, Translin-associated factor X) (PE)

Cat. Num. AAA6359550

• Gene Names: TSNAX; TRAX
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TSNAX; Polyclonal Antibody; NT (TSNAX; TRAX; Translin-associated protein X; Translin-associated factor X) (PE); Translin-associated factor X; anti-TSNAX antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-TSNAX antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: TSNAX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-62 amino acids from the N-terminal region of human TSNAX.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(TSNAX Antibody (N-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the TSNAX antibody detected the TSNAX protein (arrow).)

Immunohistochemistry (IHC)

(TSNAX Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TSNAX Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-TSNAX antibody

This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs.

Product Categories/Family for anti-TSNAX antibody

Antibodies; Proteins

References

Saus, E., et al. J Psychiatr Res 44(14):971-978(2010). Schosser, A., et al. Mol. Psychiatry 15(8):844-849(2010). Okuda, A., et al. Neuromolecular Med. 12(1):78-85(2010). Nakata, K., et al. Proc. Natl. Acad. Sci. U.S.A. 106(37):15873-15878(2009). Palo, O.M., et al. Hum. Mol. Genet. 16(20):2517-2528(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 20302159
• NCBI GeneID: 7257
• NCBI Accession #: NP_005990.1
• NCBI GenBank Nucleotide #: NM_005999
• UniProt Accession #: Q99598; B1APC6
• Molecular Weight: 33,112 Da
• NCBI Official Full Name: Homo sapiens translin-associated factor X (TSNAX), mRNA
• NCBI Official Synonym Full Names: translin-associated factor X
• NCBI Official Symbol: TSNAX
• NCBI Official Synonym Symbols: TRAX
• NCBI Protein Information: translin-associated protein X; translin-like protein
• UniProt Protein Name: Translin-associated protein X
• Protein Family: Translin-associated protein
• UniProt Gene Name: TSNAX
• UniProt Synonym Gene Names: TRAX
• UniProt Entry Name: TSNAX_HUMAN

NCBI Description

This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs. [provided by RefSeq, Jul 2008]

Uniprot Description

TSNAX: Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis. Belongs to the translin family.

Protein type: Nuclear receptor co-regulator; DNA-binding

Chromosomal Location of Human Ortholog: 1q42.1

Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus

Molecular Function: endoribonuclease activity; DNA binding; sequence-specific DNA binding; metal ion binding; single-stranded DNA binding; protein transporter activity

Biological Process: protein transport; multicellular organismal development; gene expression; spermatogenesis; cell differentiation