Rabbit TSH beta Polyclonal Antibody | anti-TSH antibody
TSH beta Antibody BIOTIN-Conjugated
Dot Blot: 1:50,000
ELISA: 1:50,000
Immunocytochemistry: 1:250
Immunofluorescence: 1:250
Immunohistochemistry: 1:250
Immunoprecipitation: 1:200
Western Blot: 1:500
Overview: The pituitary hormones, leutinizing hormone (lutropin, LH) and follicle stimulating hormone (follitropin, FSH) as well as related placental hormones, chorionic gonadotropin and CG, are referred to as gonadotropic hormones becuase of their acstion on gonad cells. Because of their similar structure and composition and glycoprotein nature, LH, TSH, GC and FSH, these hormones are often referred to as glycoprotein hormones. These hormones are heterodimeric in nature composed of two un-identical subunits, alpha and beta, which are non-covalently associated. Among humans and other species, the Alpha subunit is identical for all these hormones and is coded by a single gene, where is beta subunits are distinct but not homologous and arise from separate genes. The individual hormone subunits and peptides derived from them have shown some binding activities to their respective receptors, the association of alpha and beta subunits clearly is required for optimal activation and physiological responses elicited by these hormones. Within the heterodimeric hormones, the beta subunit confers binding activity to its respective receptor.
The TSH beta-selective antibodies were generated against a sequence within amino acid region 1-50 on human TSH beta protein. The antibodies to TSH beta can be conjugated to fluorophores and other secondary enzymes as an additional service. Western blot positive control in ready-to-use SDS-sample buffer and antigenic blocking peptides are available. Please inquire.
NCBI and Uniprot Product Information
NCBI Description
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Uniprot Description
TSHB: Indispensable for the control of thyroid structure and metabolism. Belongs to the glycoprotein hormones subunit beta family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1p13
Cellular Component: extracellular region
Molecular Function: hormone activity
Biological Process: anatomical structure morphogenesis; cell-cell signaling; G-protein coupled receptor protein signaling pathway; peptide hormone processing; response to calcium ion; response to estrogen stimulus; response to vitamin A
Disease: Hypothyroidism, Congenital, Nongoitrous, 4
Research Articles on TSH
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Product Notes
The TSH tshb (Catalog #AAA5400185) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TSH beta Antibody BIOTIN-Conjugated reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TSH beta can be used in a range of immunoassay formats including, but not limited to, Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB). Confocal Microscopy: 1:250 Dot Blot: 1:50,000 ELISA: 1:50,000 Immunocytochemistry: 1:250 Immunofluorescence: 1:250 Immunohistochemistry: 1:250 Immunoprecipitation: 1:200 Western Blot: 1:500. Researchers should empirically determine the suitability of the TSH tshb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TSH beta, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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