Western Blot (WB)
(WB Suggested Anti-TSG101 Antibody Titration: 2.5ug/mlELISA Titer: 1:62500Positive Control: NIH/3T3 cell lysate)
Rabbit TSG101 Polyclonal Antibody | anti-TSG101 antibody
TSG101 antibody - middle region
Western Blot (WB)
(WB Suggested Anti-TSG101 Antibody Titration: 2.5ug/mlELISA Titer: 1:62500Positive Control: NIH/3T3 cell lysate)
Western Blot (WB)
(WB Suggested Anti-TSG101 Antibody Titration: 2.5ug/mlELISA Titer: 1:62500Positive Control: NIH/3T3 cell lysate)
Target Description: TSG101 has a direct role in the control of growth and differentiation in primary epithelial cells. It is required for normal cell function of embryonic and adult tissues but that this gene is not a tumor suppressor for sporadic forms of breast cancer.
NCBI and Uniprot Product Information
Uniprot Description
TSG101: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; Nuclear receptor co-regulator
Cellular Component: membrane; cytoplasm; early endosome; late endosome; plasma membrane; nucleolus; endosome membrane; nucleus; endosome
Molecular Function: ubiquitin binding; protein binding; protein homodimerization activity; ligand-dependent nuclear receptor transcription coactivator activity; ubiquitin protein ligase binding; calcium-dependent protein binding; transcription corepressor activity
Biological Process: protein monoubiquitination; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; viral reproduction; non-lytic virus budding; protein modification process; cell cycle; keratinocyte differentiation; negative regulation of cell proliferation; protein transport; cell division; transport; regulation of growth; endosome to lysosome transport; regulation of cell growth; cell differentiation; negative regulation of transcription, DNA-dependent; cell cycle arrest
Research Articles on TSG101
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Product Notes
The TSG101 tsg101 (Catalog #AAA3203812) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TSG101 antibody - middle region reacts with Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast and may cross-react with other species as described in the data sheet. AAA Biotech's TSG101 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the TSG101 tsg101 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: YMPGMPSGIS AYPSGYPPNP SGYPGCPYPP AGPYPATTSS QYPSQPPVTT. It is sometimes possible for the material contained within the vial of "TSG101, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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