Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TSC2 Polyclonal Antibody at dilution 1:35)
Rabbit TSC2 Polyclonal Antibody | anti-TSC2 antibody
TSC2 Polyclonal Antibody
Gene Names
Tsc2; Rc
Reactivity
Human, Mouse, Rat
Applications
ELISA, Immunohistochemistry
Purity
Antigen Affinity Purification
Synonyms
TSC2; Polyclonal Antibody; TSC2 Polyclonal Antibody; LAM; TSC4; PPP1R160; anti-TSC2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Affinity Purification
Concentration
2.4mg/ml (varies by lot)
Sequence Length
1809
Applicable Applications for anti-TSC2 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes
ELISA: 1:2000-5000
IHC: 1:25-100
IHC: 1:25-100
Immunogen
Synthetic peptide of human TSC2
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-893 / sc-13012 / sc-892
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TSC2 Polyclonal Antibody at dilution 1:35)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TSC2 Polyclonal Antibody at dilution 1:35)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TSC2 Polyclonal Antibody at dilution 1:35)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TSC2 Polyclonal Antibody at dilution 1:35)
Related Product Information for anti-TSC2 antibody
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
194,006 Da
NCBI Official Full Name
tuberin
NCBI Official Synonym Full Names
tuberous sclerosis 2
NCBI Official Symbol
Tsc2
NCBI Official Synonym Symbols
Rc
NCBI Protein Information
tuberin
UniProt Protein Name
Tuberin
Protein Family
UniProt Gene Name
Tsc2
UniProt Entry Name
TSC2_RAT
NCBI Description
acts as a tumor suppressor; may play a role in cell cycle regulation; acute phase response, and negative regulation of cell proliferation [RGD, Feb 2006]
Uniprot Description
In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.
Research Articles on TSC2
Similar Products
Product Notes
The TSC2 tsc2 (Catalog #AAA2542891) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TSC2 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TSC2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). ELISA: 1:2000-5000 IHC: 1:25-100. Researchers should empirically determine the suitability of the TSC2 tsc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TSC2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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