Western Blot (WB)
(Anti- TRPV5 Picoband antibody, MBS178072, Western blottingAll lanes: Anti TRPV5 (MBS178072) at 0.5ug/mlLane 1: Rat Pancreas Tissue Lysate at 50ugLane 2: Rat Lung Tissue Lysate at 50ugLane 3: Rat Intestine Tissue Lysate at 50ugLane 4: SW620 Whole Cell Lysate at 40ugLane 5: COLO320 Whole Cell Lysate at 40ugLane 6: 293T Whole Cell Lysate at 40ugPredicted bind size: 83KDObserved bind size: 83KD)
anti-Human, Rat TRPV5 Polyclonal Antibody | anti-TRPV5 antibody
Anti-TRPV5 Antibody
Western Blot (WB)
(Anti- TRPV5 Picoband antibody, MBS178072, Western blottingAll lanes: Anti TRPV5 (MBS178072) at 0.5ug/mlLane 1: Rat Pancreas Tissue Lysate at 50ugLane 2: Rat Lung Tissue Lysate at 50ugLane 3: Rat Intestine Tissue Lysate at 50ugLane 4: SW620 Whole Cell Lysate at 40ugLane 5: COLO320 Whole Cell Lysate at 40ugLane 6: 293T Whole Cell Lysate at 40ugPredicted bind size: 83KDObserved bind size: 83KD)
Western Blot (WB)
(Anti- TRPV5 Picoband antibody, MBS178072, Western blottingAll lanes: Anti TRPV5 (MBS178072) at 0.5ug/mlLane 1: Rat Pancreas Tissue Lysate at 50ugLane 2: Rat Lung Tissue Lysate at 50ugLane 3: Rat Intestine Tissue Lysate at 50ugLane 4: SW620 Whole Cell Lysate at 40ugLane 5: COLO320 Whole Cell Lysate at 40ugLane 6: 293T Whole Cell Lysate at 40ugPredicted bind size: 83KDObserved bind size: 83KD)
Background: Transient receptor potential cation channel subfamily V member 5 is a protein that in humans is encoded by the TRPV5 gene. This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. And this protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. In addition, TRPV5 is mainly expressed in kidney epithelial cells, where it plays an important role in the reabsorption of Ca2+. Genetic deletion of TRPV5 in mice leads to Ca2+ loss in the urine, and consequential hyperparathyroidism, and bone loss.
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. [provided by RefSeq, Jul 2008]
Uniprot Description
TRPV5: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV5 sub-subfamily.
Protein type: Channel, cation; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q35
Cellular Component: apical plasma membrane; integral to plasma membrane; plasma membrane
Molecular Function: calcium channel activity; calmodulin binding; protein binding
Biological Process: calcium ion transport; protein tetramerization
Research Articles on TRPV5
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Product Notes
The TRPV5 trpv5 (Catalog #AAA178072) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-TRPV5 Antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TRPV5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot Concentration: 0.1-0.5ug/ml. Researchers should empirically determine the suitability of the TRPV5 trpv5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRPV5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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