Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TRPM2 Polyclonal Antibody at dilution 1:30)
Rabbit anti-Human TRPM2 Polyclonal Antibody | anti-TRPM2 antibody
TRPM2 Polyclonal Antibody
IHC: 1:25-100
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TRPM2 Polyclonal Antibody at dilution 1:30)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TRPM2 Polyclonal Antibody at dilution 1:30)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TRPM2 Polyclonal Antibody at dilution 1:30)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TRPM2 Polyclonal Antibody at dilution 1:30)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]
Uniprot Description
TRPM2: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, calcium; EC 3.6.1.13; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: cytoplasmic vesicle membrane; integral to plasma membrane; lysosomal membrane; lysosome; plasma membrane
Molecular Function: calcium channel activity; calcium ion binding; calcium-release channel activity; cation channel activity; hydrolase activity
Biological Process: calcium ion transport; dendritic cell chemotaxis; regulation of filopodium formation; release of sequestered calcium ion into cytosol; response to purine; thermoregulation
Research Articles on TRPM2
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Product Notes
The TRPM2 trpm2 (Catalog #AAA2542569) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TRPM2 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TRPM2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). ELISA: 1:2000-5000 IHC: 1:25-100. Researchers should empirically determine the suitability of the TRPM2 trpm2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRPM2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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