Western Blot (WB)
(Western Blot analysis of HeLa cells using TRPC3 Polyclonal Antibody)
Rabbit TRPC3 Polyclonal Antibody | anti-TRPC3 antibody
TRPC3 Antibody
ELISA: 1:20000
Western Blot (WB)
(Western Blot analysis of HeLa cells using TRPC3 Polyclonal Antibody)
Western Blot (WB)
(Western Blot analysis of HeLa cells using TRPC3 Polyclonal Antibody)
NCBI and Uniprot Product Information
Observed: 100 kDa
NCBI Description
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Description
TRPC3 iso3: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, cation
Chromosomal Location of Human Ortholog: 4q27
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: protein binding; store-operated calcium channel activity; calcium channel activity
Biological Process: axon guidance; platelet activation; calcium ion transport; phototransduction; response to calcium ion; blood coagulation; transmembrane transport; response to ATP
Disease: Spinocerebellar Ataxia 41
Research Articles on TRPC3
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Product Notes
The TRPC3 trpc3 (Catalog #AAA7117719) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TRPC3 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TRPC3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:500-1:2000 ELISA: 1:20000. Researchers should empirically determine the suitability of the TRPC3 trpc3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRPC3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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