Rabbit anti-Human TrkC Polyclonal Antibody | anti-TrkC antibody

TrkC (GP145-TrkC, NTRK3, NT-3 Growth Factor Receptor, Neurotrophic Tyrosine Kinase Receptor Type 3, TrkC Tyrosine Kinase) (HRP)

Cat. Num. AAA6503690

• Gene Names: NTRK3; TRKC; gp145(trkC)
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Ammonium Sulfate Precipitation.
• Synonyms: TrkC; Polyclonal Antibody; TrkC (GP145-TrkC; NTRK3; NT-3 Growth Factor Receptor; Neurotrophic Tyrosine Kinase Receptor Type 3; TrkC Tyrosine Kinase) (HRP); anti-TrkC antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human TrkC.
• Purity/Purification: Purified by Ammonium Sulfate Precipitation.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-TrkC antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:50-1:100; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: His tag recombinant protein of human TrkC.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.

Western Blot (WB)

(TrkC Antibody western blot analysis in U87-MG cell line lysates (35ug/lane).This demonstrates the TrkC antibody detected the TrkC protein (arrow).)

Product Categories/Family for anti-TrkC antibody

Antibodies; Receptors; Tyrosine Kinase

References

1. McGregor, L.M., et al., Genomics 22(2):267-272 (1994). 2. Shelton, D.L., et al., J. Neurosci. 15(1 Pt 2), 477-491 (1995).

NCBI and Uniprot Product Information

• NCBI GI #: 59889562
• NCBI GeneID: 4916
• NCBI Accession #: NP_001012338.1
• NCBI GenBank Nucleotide #: NM_001012338.2
• UniProt Accession #: Q16288; O75682; Q12827; Q16289
• Molecular Weight: 94,428 Da
• NCBI Official Full Name: NT-3 growth factor receptor isoform a
• NCBI Official Synonym Full Names: neurotrophic tyrosine kinase, receptor, type 3
• NCBI Official Symbol: NTRK3
• NCBI Official Synonym Symbols: TRKC; gp145(trkC)
• NCBI Protein Information: NT-3 growth factor receptor; GP145-TrkC; ETV6-NTRK3 fusion; tyrosine kinase receptor C; ETS related protein-neurotrophic receptor tyrosine kinase fusion protein
• UniProt Protein Name: NT-3 growth factor receptor
• UniProt Gene Name: NTRK3
• UniProt Synonym Gene Names: TRKC; Trk-C
• UniProt Entry Name: NTRK3_HUMAN

NCBI Description

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Uniprot Description

TrkC: a receptor tyrosine kinase of the TRK family. Receptor for neurotrophin-3 (NT-3). Known substrates for the trk receptors are SHC, PI-3 kinase, and PLCG1. Four alternatively spliced isoforms are known.

Protein type: Kinase, protein; EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; Trk family

Chromosomal Location of Human Ortholog: 15q25

Cellular Component: integral to plasma membrane; cytoplasm; receptor complex

Molecular Function: neurotrophin binding; protein binding; ephrin receptor binding; p53 binding; transmembrane receptor protein tyrosine kinase activity; neurotrophin receptor activity; ATP binding

Biological Process: circadian rhythm; mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; positive regulation of positive chemotaxis; activation of MAPK activity; positive regulation of axon extension involved in regeneration; protein amino acid autophosphorylation; activation of protein kinase B; neuron migration; positive regulation of peptidyl-serine phosphorylation; response to ethanol; negative regulation of protein amino acid phosphorylation; positive regulation of cell proliferation; negative regulation of astrocyte differentiation; modification by virus of host cell transcription; neuron fate specification; response to axon injury; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration; response to corticosterone stimulus