Rabbit anti-Human TREM1 Polyclonal Antibody | anti-TREM1 antibody

TREM1 Antibody

Cat. Num. AAA153717

• Gene Names: TREM1; CD354; TREM-1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: TREM1 Antibody is affinity chromatography purified via peptide column.
• Synonyms: TREM1; Polyclonal Antibody; TREM1 Antibody; CD354; TREM-1; Triggering receptor expressed on myeloid cells 1; Triggering receptor expressed on monocytes 1; triggering receptor expressed on myeloid cells; anti-TREM1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: TREM1 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 234

• Applicable Applications for anti-TREM1 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: TREM1 antibody can be used for detection of TREM1 by Western blot at 1 - 2 mug/mL.
• Conjugate: Unconjugated
• Immunogen: Rabbit polyclonal TREM1 antibody was raised against a 17 amino acid peptide near the amino terminus of human TREM1.
• Buffer: TREM1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: TREM1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.

Western Blot (WB)

(Western blot analysis of TREM1 in 293 cell lysate with TREM1 antibody at (A) 1 and (B) 2 μg/mL.)

Related Product Information for anti-TREM1 antibody

TREM1 Antibody: TREM1 (triggering receptor expressed on myeloid cells 1) is a receptor belonging to the Ig superfamily that amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. It is thought that TREM1 other related TREM proteins such as TREM2 act to modulate the inflammatory response. TREM1 has also been linked to inflammatory bowel disease resulting in enhanced production of TNF, IL-6, IL-8, and MCP-1.

NCBI and Uniprot Product Information

• NCBI GI #: 8924262
• NCBI GeneID: 54210
• NCBI Accession #: NP_061113
• NCBI GenBank Nucleotide #: NM_018643.3
• UniProt Accession #: Q9NP99; Q53FL8; Q5T2C9; Q86YU1; B4DWG2; K7EJW1
• Molecular Weight: Predicted: 26 kDa
• NCBI Official Full Name: triggering receptor expressed on myeloid cells 1 isoform 1
• NCBI Official Synonym Full Names: triggering receptor expressed on myeloid cells 1
• NCBI Official Symbol: TREM1
• NCBI Official Synonym Symbols: CD354; TREM-1
• NCBI Protein Information: triggering receptor expressed on myeloid cells 1; triggering-receptor TREM1; triggering receptor expressed on monocytes 1
• UniProt Protein Name: Triggering receptor expressed on myeloid cells 1
• Protein Family: Triggering receptor expressed on myeloid cells
• UniProt Gene Name: TREM1
• UniProt Synonym Gene Names: TREM-1
• UniProt Entry Name: TREM1_HUMAN

NCBI Description

This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

Uniprot Description

TREM1: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: plasma membrane; integral to membrane; extracellular region

Molecular Function: receptor activity

Biological Process: neutrophil chemotaxis; innate immune response; cytokine secretion during immune response; blood coagulation; chemokine metabolic process; leukocyte migration; humoral immune response