Rabbit anti-Human Trefoil Factor 3 Polyclonal Antibody | anti-TFF3 antibody

Trefoil Factor 3 (Intestinal Trefoil Factor, hITF, Polypeptide P1.B, hP1.B, TFF3, ITF, TFI)

Cat. Num. AAA627442

• Gene Names: TFF3; ITF; P1B; TFI
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Trefoil Factor 3; Polyclonal Antibody; Trefoil Factor 3 (Intestinal Trefoil Factor; hITF; Polypeptide P1.B; hP1.B; TFF3; ITF; TFI); Anti -Trefoil Factor 3 (Intestinal Trefoil Factor; anti-TFF3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human TFF3.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a lyophilized powder from PBS, 0.05% sodium azide.

• Applicable Applications for anti-TFF3 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot and ELISA..; Dilution: Western Blot: 1-10ug/ml using Chemiluminescence; ELISA: 1:100,000; 50-100ng of control peptide/well
• Immunogen: Synthetic peptide corresponding to 16aa near the c-Terminal of mouse TFF3 (KLH) (Accession #Q96NX0). Species Sequence Homology: porcine and sheep, 68%; rat and mouse, 68%.
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-TFF3 antibody

Minor disruption of the GI surface layer of the cells occurs frequently, such that maintaining epithelial integrity is of crucial importance. Normal epithelial repair requires restitution and regeneration. During restitution, within minutes after injury, epithelial cells spread and migrate across the basement membrane to re-establish surface cell continuity.

Product Categories/Family for anti-TFF3 antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 281485608
• NCBI GeneID: 7033
• NCBI Accession #: NP_003217.3
• NCBI GenBank Nucleotide #: NM_003226.3
• UniProt Accession #: Q07654; Q96NX0; Q9UDA5
• Molecular Weight: 8,641 Da
• NCBI Official Full Name: trefoil factor 3
• NCBI Official Synonym Full Names: trefoil factor 3 (intestinal)
• NCBI Official Symbol: TFF3
• NCBI Official Synonym Symbols: ITF; P1B; TFI
• NCBI Protein Information: trefoil factor 3; polypeptide P1.B; OTTHUMP00000109348; OTTHUMP00000109349
• UniProt Protein Name: Trefoil factor 3
• Protein Family: Trefoil factor
• UniProt Gene Name: TFF3
• UniProt Synonym Gene Names: ITF; TFI
• UniProt Entry Name: TFF3_HUMAN

NCBI Description

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq]

Uniprot Description

TFF3: Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: proteinaceous extracellular matrix; extracellular region; secretory granule

Biological Process: response to peptide hormone stimulus; digestion; defense response