Goat TRAC-1/RNF125 Polyclonal Antibody | anti-RNF125 antibody

Goat anti-TRAC-1/RNF125 Antibody

Cat. Num. AAA420130

• Gene Names: RNF125; TNORS; TRAC1; TRAC-1
• Reactivity: Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
• Applications: ELISA
• Purity: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Synonyms: TRAC-1/RNF125; Polyclonal Antibody; Goat anti-TRAC-1/RNF125 Antibody; RNF125; FLJ20456; MGC21737; ring finger protein 125; TRAC1; T-cell ring protein identified in activation screen; RNF125 antibody; FLJ20456 antibody; MGC21737 antibody; ring finger protein 125 antibody; TRAC1 antibody; T-cell ring protein identified in activation screen antibody; TRAC-1 / RNF125; anti-RNF125 antibody

• Host: Goat
• Reactivity: Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
• Clonality: Polyclonal
• Purity/Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Form/Format: Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Concentration: 100ug specific antibody in 200ul (varies by lot)
• Sequence: RSLLEYVNHSNTT
• Sequence Length: 232

• Applicable Applications for anti-RNF125 antibody: Peptide ELISA (EIA)
• Application Notes: Peptide ELISA: Antibody detection limit dilution 1: 8000.; Western Blot: Preliminary experiments gave no signal but low background in Human Brain and Ovary lysates at up to 1ug/ml.
• Immunogen: Peptide with sequence C-RSLLEYVNHSNTT, from the C Terminus of the protein sequence according to NP_060301.2.
• Epitope: C Terminus
• Preparation and Storage: Aliquot and store at -20 degree C. Minimize freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 37595555
• NCBI GeneID: 54941
• NCBI Accession #: NP_060301.2
• NCBI GenBank Nucleotide #: NM_017831.3
• Molecular Weight: 26,454 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase RNF125
• NCBI Official Synonym Full Names: ring finger protein 125, E3 ubiquitin protein ligase
• NCBI Official Symbol: RNF125
• NCBI Official Synonym Symbols: TNORS; TRAC1; TRAC-1
• NCBI Protein Information: E3 ubiquitin-protein ligase RNF125
• UniProt Protein Name: E3 ubiquitin-protein ligase RNF125
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: RNF125
• UniProt Synonym Gene Names: TRAC-1
• UniProt Entry Name: RN125_HUMAN

NCBI Description

This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012]

Uniprot Description

RNF125: E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins.

Protein type: Ligase; EC 6.3.2.19; EC 6.3.2.-; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 18q12.1

Cellular Component: intracellular

Molecular Function: ligase activity; ubiquitin conjugating enzyme binding; zinc ion binding

Biological Process: adaptive immune response; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination

Disease: Tenorio Syndrome