Western Blot (WB)
(TPSD1 Antibody (C-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the TPSD1 antibody detected the TPSD1 protein (arrow).)
Rabbit anti-Human TPSD1 Polyclonal Antibody | anti-TPSD1 antibody
TPSD1 Antibody (C-term)
Western Blot (WB)
(TPSD1 Antibody (C-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the TPSD1 antibody detected the TPSD1 protein (arrow).)
Western Blot (WB)
(TPSD1 Antibody (C-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the TPSD1 antibody detected the TPSD1 protein (arrow).)
Immunohistochemistry (IHC)
(TPSD1 antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TPSD1 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(TPSD1 antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TPSD1 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
proteases, the peptidase family S1. Tryptases are enzymatically
active only as heparin-stabilized tetramers, and they are resistant
to all known endogenous proteinase inhibitors. Several tryptase
genes are clustered on chromosome 16p13.3. These genes are
characterized by several distinct features. They have a highly
conserved 3' UTR and contain tandem repeat sequences at the 5'
flank and 3' UTR which are thought to play a role in regulation of
the mRNA stability. Although this gene may be an exception, most of
the tryptase genes have an intron immediately upstream of the
initiator Met codon, which separates the site of transcription
initiation from protein coding sequence. This feature is
characteristic of tryptases but is unusual in other genes.
Tryptases have been implicated as mediators in the pathogenesis of
asthma and other allergic and inflammatory disorders. TPSD1 was
once considered to be a pseudogene, although it is now believed to
be a functional gene that encodes a protein.
Caughey, G.H. J. Allergy Clin. Immunol. 117(6):1411-1414(2006)
Wang, H.W., et al. J. Immunol. 169(9):5145-5152(2002)
Caughey, G.H. Mol. Immunol. 38 (16-18), 1353-1357 (2002) :
Soto, D., et al. Clin. Exp. Allergy 32(7):1000-1006(2002)
NCBI and Uniprot Product Information
NCBI Description
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. Although this gene may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. This gene was once considered to be a pseudogene, although it is now believed to be a functional gene that encodes a protein. [provided by RefSeq, Jul 2008]
Uniprot Description
TPSD1: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Belongs to the peptidase S1 family. Tryptase subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide; EC 3.4.21.59; Protease
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: extracellular region
Molecular Function: serine-type peptidase activity; serine-type endopeptidase activity
Biological Process: proteolysis
Research Articles on TPSD1
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Product Notes
The TPSD1 tpsd1 (Catalog #AAA9201886) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 164-193. The TPSD1 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TPSD1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the TPSD1 tpsd1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TPSD1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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