Rabbit anti-Human TPSB2 Polyclonal Antibody | anti-TPSB2 antibody

TPSB2 Rabbit pAb

Cat. Num. AAA4754518

• Gene Names: TPSB2; TPS2; tryptaseB; tryptaseC
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: TPSB2; Polyclonal Antibody; TPSB2 Rabbit pAb; TPS2; tryptaseB; tryptaseC; anti-TPSB2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Purity/Purification: Affinity purified
• Form/Format: -20 degree C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

• Applicable Applications for anti-TPSB2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: WB: 1:200-1:1000
• Immunogen: Full length fusion protein
• Conjugation: Unconjugated
• Molecular Function: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
• Modification: Unmodified
• Cell Position: Secreted
• Preparation and Storage: Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Gel: 8%SDS-PAGE, Lysate: 20 ug, Lane: Human fetal muscle tissue lysate, Primary antibody: 123395(TPSB2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds)

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 123395(TPSB2 Antibody) at dilution 1/20. (Original magnification: ×200))

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 123395(TPSB2 Antibody) at dilution 1/20. (Original magnification: ×200))

Product Categories/Family for anti-TPSB2 antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 20809954
• NCBI GeneID: 64499
• UniProt Accession #: P20231; O95827; Q15664; Q9UQI6; Q9UQI7; D2E6S0; D2E6S2
• Molecular Weight: 30,515 Da
• NCBI Official Full Name: Homo sapiens tryptase beta 2, mRNA
• NCBI Official Synonym Full Names: tryptase beta 2 (gene/pseudogene)
• NCBI Official Symbol: TPSB2
• NCBI Official Synonym Symbols: TPS2; tryptaseB; tryptaseC
• NCBI Protein Information: tryptase beta-2
• UniProt Protein Name: Tryptase beta-2
• Protein Family: Tryptase
• UniProt Gene Name: TPSB2
• UniProt Synonym Gene Names: TPS2; Tryptase-2
• UniProt Entry Name: TRYB2_HUMAN

NCBI Description

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]