Rabbit anti-Human TPR Polyclonal Antibody | anti-TPR antibody
TPR (C-Term) Rabbit pAb
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]
Uniprot Description
TPR: a large coiled-coil nuclear pore protein that forms filamentous structures extending from nuclear pore complexes (NPCs) into the perinucleolar region. Together with Lamina-associated polypeptide 2 (LAP2) family members and Nup153, forms structural links between the nuclear lamina and the internal nuclear matrix. In interphase, localizes to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus. Involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Translocations between human TPR and TrkA, MET, and RAF genes are oncogenic. Its N-terminus is involved in activation of oncogenic kinases.
Protein type: Membrane protein, peripheral; Nuclear envelope; Nucleoporin; Oncoprotein
Chromosomal Location of Human Ortholog: 1q31.1
Cellular Component: cytoplasm; cytoplasmic dynein complex; extrinsic to membrane; kinetochore; nuclear envelope; nuclear inclusion body; nuclear membrane; nuclear pore; nucleoplasm; nucleus
Molecular Function: chromatin binding; heat shock protein binding; mitogen-activated protein kinase binding; mRNA binding; nucleocytoplasmic transporter activity; protein anchor; protein binding; protein homodimerization activity; RNA binding; transporter activity; tubulin binding
Biological Process: mitotic cell cycle spindle assembly checkpoint; mitotic nuclear envelope disassembly; mRNA export from nucleus; mRNA export from nucleus during heat stress; negative regulation of RNA export from nucleus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of translational initiation; nuclear matrix organization and biogenesis; nuclear pore complex assembly; nuclear pore organization and biogenesis; nuclear translocation of MAPK; positive regulation of heterochromatin formation; positive regulation of protein export from nucleus; positive regulation of protein import into nucleus; protein export from nucleus; protein import into nucleus; protein sumoylation; regulation of protein export from nucleus; regulation of protein import into nucleus; regulation of protein stability; RNA export from nucleus; RNA import into nucleus; tRNA export from nucleus; viral reproduction; viral transcription
Research Articles on TPR
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Product Notes
The TPR tpr (Catalog #AAA8557402) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TPR (C-Term) Rabbit pAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TPR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:2000. Researchers should empirically determine the suitability of the TPR tpr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TPR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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