Goat TPCN2 Polyclonal Antibody | anti-TPCN2 antibody
Goat anti-TPCN2 Antibody
Western Blot: Preliminary experiments gave an approx 30kDa band in Human Brain (Cerebral Cortex), Kidney and Liver lysates after 0.5ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 85.2kDa according to NP_620714.2. The 30kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009]
Uniprot Description
TPCN2: Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily.
Protein type: Transporter, ion channel; Membrane protein, integral; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 11q13.3
Cellular Component: endosome membrane; integral to membrane; lysosomal membrane; lysosome; plasma membrane
Molecular Function: identical protein binding; protein binding; protein kinase binding; voltage-gated calcium channel activity
Biological Process: calcium-mediated signaling; cellular calcium ion homeostasis; lysosome organization and biogenesis; regulation of autophagy; release of sequestered calcium ion into cytosol; response to vitamin D; smooth muscle contraction
Disease: Skin/hair/eye Pigmentation, Variation In, 10
Research Articles on TPCN2
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Product Notes
The TPCN2 tpcn2 (Catalog #AAA422108) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-TPCN2 Antibody reacts with Expected from sequence similarity: Human and may cross-react with other species as described in the data sheet. AAA Biotech's TPCN2 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Preliminary experiments gave an approx 30kDa band in Human Brain (Cerebral Cortex), Kidney and Liver lysates after 0.5ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 85.2kDa according to NP_620714.2. The 30kDa band was successfully blocked by incubation with the immunizing peptide. Researchers should empirically determine the suitability of the TPCN2 tpcn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: EDELTERLSQ HPH. It is sometimes possible for the material contained within the vial of "TPCN2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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