Rabbit anti-Human TP73 Polyclonal Antibody | anti-TP73 antibody

TP73 Antibody

Cat. Num. AAA9408739

• Gene Names: TP73; P73
• Reactivity: Human
• Applications: Western Blot
• Purity: Antigen affinity purification.
• Synonyms: TP73; Polyclonal Antibody; TP73 Antibody; P73; anti-TP73 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total TP73 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 0.7 mg/ml (varies by lot)
• Sequence Length: 587

• Applicable Applications for anti-TP73 antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:200-1:1000
• Immunogen Type: Recombinant Protein
• Immunogen Description: Fusion protein corresponding to a region derived from internal residues of human tumor protein p73
• Target Name: TP73
• Preparation and Storage: Store at -20 degree C

Testing Data

(Gel: 10%SDS-PAGE Lysates (from left to right): Human brain malignant glioma tissue Amount of lysate: 60ug per lane Primary antibody: 1/300 dilution Secondary antibody dilution: 1/8000 Exposure time: 2 minutes)

Related Product Information for anti-TP73 antibody

This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined.

Product Categories/Family for anti-TP73 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 187828902
• NCBI GeneID: 7161
• NCBI Accession #: NP_001119712.1
• NCBI GenBank Nucleotide #: NM_001126240.2
• UniProt Accession #: O15350; O15351; Q17RN8; Q5TBV5; Q5TBV6; Q8NHW9; Q8TDY5; Q8TDY6; B7Z7J4; B7Z8Z1; B7Z9C1; C9J521
• Molecular Weight: 61,694 Da
• NCBI Official Full Name: tumor protein p73 isoform b
• NCBI Official Synonym Full Names: tumor protein p73
• NCBI Official Symbol: TP73
• NCBI Official Synonym Symbols: P73
• NCBI Protein Information: tumor protein p73
• UniProt Protein Name: Tumor protein p73
• Protein Family: Tumor protein
• UniProt Gene Name: TP73
• UniProt Synonym Gene Names: P73
• UniProt Entry Name: P73_HUMAN

NCBI Description

This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]

Uniprot Description

Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.