Rabbit anti-Human, Mouse TOX Polyclonal Antibody | anti-TOX antibody

TOX Antibody

Cat. Num. AAA9629757

• Gene Names: TOX; TOX1
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: TOX; Polyclonal Antibody; TOX Antibody; KIAA0808; Thymocyte selection-associated high mobility group box; Thymocyte selection-associated high mobility group box protein TOX; Thymus high mobility group box protein TOX; Thymus high mobility group box protein; mouse; homolog of TOX1; TOX 1; Tox; TOX_HUMAN; TOX1; anti-TOX antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: TOX Antibody detects endogenous levels of TOX.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-TOX antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human TOX.
• Conjugation: Unconjugated
• Subunit Structure: Interacts with HBO1 complex composed at least of KAT7/HBO1, ING4, MEAF6, and JADE2; this complex is involved in histone acetylation. Interacts with DNMT1, LEO1, PAF1, SAP130 and SIN3A; these interactors regulate chromatin remodeling. Interacts with an array of proteins involved in RNA processing and translation and DNA replication.
• Tissue Specificity: Expressed in NK cells. Highly expressed in tumor-infiltrating CD8-positive T cells (at protein level).
• Function: Transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis (By similarity). Binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA. During cortical development, controls the neural stem cell pool by inhibiting the switch from proliferative to differentiating progenitors. Beyond progenitor cells, promotes neurite outgrowth in newborn neurons migrating to reach the cortical plate. May activate or repress critical genes for neural stem cell fate such as SOX2, EOMES and ROBO2 (By similarity). Plays an essential role in the development of lymphoid tissue-inducer (LTi) cells, a subset necessary for the formation of secondary lymphoid organs: peripheral lymph nodes and Peyer's patches. Acts as a developmental checkpoint and regulates thymocyte positive selection toward T cell lineage commitment. Required for the development of various T cell subsets, including CD4-positive helper T cells, CD8-positive cytotoxic T cells, regulatory T cells and CD1D-dependent natural killer T (NKT) cells. Required for the differentiation of common lymphoid progenitors (CMP) to innate lymphoid cells (ILC) (By similarity). May regulate the NOTCH-mediated gene program, promoting differentiation of the ILC lineage. Required at the progenitor phase of NK cell development in the bone marrow to specify NK cell lineage commitment (By similarity). Upon chronic antigen stimulation, diverts T cell development by promoting the generation of exhaustive T cells, while suppressing effector and memory T cell programming. May regulate the expression of genes encoding inhibitory receptors such as PDCD1 and induce the exhaustion program, to prevent the overstimulation of T cells and activation-induced cell death (By similarity).
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-TOX antibody

Nucleus; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 109895218
• NCBI GeneID: 9760
• UniProt Accession #: O94900; Q96AV5
• Molecular Weight: 526
• NCBI Official Full Name: Thymocyte selection-associated high mobility group box protein TOX
• NCBI Official Synonym Full Names: thymocyte selection-associated high mobility group box
• NCBI Official Symbol: TOX
• NCBI Official Synonym Symbols: TOX1
• NCBI Protein Information: thymocyte selection-associated high mobility group box protein TOX; thymus high mobility group box protein TOX
• UniProt Protein Name: Thymocyte selection-associated high mobility group box protein TOX
• Protein Family: Toxin
• UniProt Gene Name: TOX
• UniProt Synonym Gene Names: KIAA0808
• UniProt Entry Name: TOX_HUMAN

NCBI Description

The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.[provided by RefSeq, Apr 2009]

Uniprot Description

TOX: May play a role in regulating T-cell development.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 8q12.1

Cellular Component: nucleus

Molecular Function: DNA binding; chromatin binding

Biological Process: chromatin remodeling; regulation of transcription, DNA-dependent