Rabbit TOR1A Polyclonal Antibody | anti-TOR1A antibody

TOR1A Polyclonal Antibody

Cat. Num. AAA3008062

• Gene Names: TOR1A; DQ2; DYT1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: TOR1A; Polyclonal Antibody; TOR1A Polyclonal Antibody; DQ2; Dystonia 1; Dystonia 1 protein; Dystonia 1 torsion; Dyt1; Tor1a; Torsin 1A; Torsin A; Torsin family 1 member A; Torsin family 1; member A (torsin A); anti-TOR1A antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TOR1A polyclonal antibody detects endogenous levels of TOR1A protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 332

• Applicable Applications for anti-TOR1A antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200
• Immunogen: Recombinant full length Human TOR1A.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of TOR1A polyclonal antibody)

Related Product Information for anti-TOR1A antibody

A mutation of the DYT1 gene, which codes for TorsinA, has been identified as the cause of one form of autosomal dominantly inherited dystonia. Early-onset torsion dystonia is a movement disorder, characterized by twisting muscle contractures, that begins in childhood. Symptoms are believed to result from altered neuronal communication in the basal ganglia. TorsinA comprises 332 amino acids. TorsinA is widely expressed throughout the mouse central nervous system and is detected in the majority of neurons in nearly all regions. The proteins display cytoplasmic distribution, although in some types of neurons localization is perinuclear. TorsinA often performs chaperone-like functions that assist in the assembly, operation, or dis-assembly of protein complexes. The gene which encodes TorsinA has high homology to three additional mammalian genes and a nematode gene and distal similarity to the family of heat-shock proteins and the Clp protease family. The gene which encodes TorsinA maps to human chromosome 9q34.

NCBI and Uniprot Product Information

• NCBI GI #: 13878817
• NCBI GeneID: 1861
• UniProt Accession #: O14656
• Molecular Weight: ~ 38kDa
• NCBI Official Full Name: Torsin-1A
• NCBI Official Synonym Full Names: torsin family 1 member A
• NCBI Official Symbol: TOR1A
• NCBI Official Synonym Symbols: DQ2; DYT1
• NCBI Protein Information: torsin-1A
• UniProt Protein Name: Torsin-1A
• Protein Family: Torsin
• UniProt Gene Name: TOR1A
• UniProt Synonym Gene Names: DQ2; DYT1; TA; TORA
• UniProt Entry Name: TOR1A_HUMAN

NCBI Description

The protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1. [provided by RefSeq, Jul 2008]

Uniprot Description

TOR1A: May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and nesprin-3/C14orf49, leaving nuclear pores and SUN1 unchanged. May form homohexamers. Interacts with TOR1AIP1 and TOR1AIP2. Interacts with KLHL14, preferentially when ATP-free. Widely expressed. Highest levels in kidney and liver. Not detected in spleen. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also high expression in the spinal cord. Belongs to the clpA/clpB family. Torsin subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: synaptic vesicle; nuclear membrane; transport vesicle; cytoskeleton; growth cone; cytoplasmic vesicle membrane; membrane; intracellular membrane-bound organelle; endoplasmic reticulum lumen; nuclear envelope; cell junction; secretory granule

Molecular Function: protein binding; kinesin binding; cytoskeletal protein binding; ATPase activity; unfolded protein binding; misfolded protein binding; ATP binding

Biological Process: protein deneddylation; chaperone cofactor-dependent protein folding; organelle organization and biogenesis; synaptic vesicle transport; regulation of dopamine uptake; intermediate filament cytoskeleton organization and biogenesis; response to oxidative stress; cell adhesion; neurite development; nuclear membrane organization and biogenesis; protein homooligomerization

Disease: Dystonia 1, Torsion, Autosomal Dominant