Western Blot (WB)
(WB Suggested Anti-TOB1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Jurkat cell lysate)
Rabbit TOB1 Polyclonal Antibody | anti-TOB1 antibody
TOB1 antibody - middle region
Western Blot (WB)
(WB Suggested Anti-TOB1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Jurkat cell lysate)
Western Blot (WB)
(WB Suggested Anti-TOB1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Jurkat cell lysate)
Target Description: This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Uniprot Description
TOB1: Anti-proliferative protein that interacts with the erbB- 2 receptor tyrosine kinase. May physically and/or functionally interact with protein-tyrosine kinase receptors. Belongs to the BTG family.
Protein type: Adaptor/scaffold; Cell cycle regulation
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: cytoplasm; nucleus; CCR4-NOT complex
Molecular Function: protein binding; SH3/SH2 adaptor activity; SMAD binding; receptor tyrosine kinase binding; transcription corepressor activity
Biological Process: negative regulation of cell proliferation; positive regulation of signal transduction; negative regulation of translation; negative regulation of osteoblast differentiation; SMAD protein nuclear translocation; negative regulation of BMP signaling pathway
Research Articles on TOB1
Similar Products
Product Notes
The TOB1 tob1 (Catalog #AAA3210610) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TOB1 antibody - middle region reacts with Cow, Dog, Horse, Human, Mouse, Pig, Rat, Yeast and may cross-react with other species as described in the data sheet. AAA Biotech's TOB1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the TOB1 tob1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: DLLKQKAISS SMHSLYGLGL GSQQQPQQQQ QPAQPPPPPP PPQQQQQQKT. It is sometimes possible for the material contained within the vial of "TOB1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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