Rabbit anti-Human, Mouse TNKS2 Polyclonal Antibody | anti-TNKS2 antibody
TNKS2 Antibody
Gene Names
TNKS2; TNKL; ARTD6; TANK2; pART6; PARP5B; PARP5C; PARP-5b; PARP-5c
Reactivity
Human, Mouse
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
TNKS2; Polyclonal Antibody; TNKS2 Antibody; ADP-ribosyltransferase diphtheria toxin-like 6; ARTD6; PARP 5b; PARP 5c; PARP-5b; PARP-5c; PARP5B; PARP5C; pART6; Poly [ADP ribose] polymerase 5B; Poly [ADP-ribose] polymerase 5B; TANK2; Tankyrase 2; Tankyrase II; Tankyrase like protein; Tankyrase related protein; Tankyrase TRF1 interacting ankyrin related ADP ribose polymerase 2; Tankyrase-2; Tankyrase-like protein; Tankyrase-related protein; TNKL; TNKS 2; TNKS-2; TNKS2_HUMAN; TRF1 Interacting Ankyrin Related ADP ribose polymerase 2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; anti-TNKS2 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
TNKS2 Antibody detects endogenous levels of TNKS2.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-TNKS2 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human TNKS2.
Conjugation
Unconjugated
Post Translational Modifications
Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated; this leads to degradation.ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer.
Subunit Structure
Oligomerizes and associates with TNKS. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of Grb14 and TRF1 with its ankyrin repeat region. Interacts with HIF1AN. Interacts with RNF146; this interaction leads to ubiquitination and proteasomal degradation. Interacts with NUMA1.
Tissue Specificity
Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain.
Function
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity.
Note
Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-TNKS2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
126,918 Da
NCBI Official Full Name
tankyrase-2
NCBI Official Synonym Full Names
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
NCBI Official Symbol
TNKS2
NCBI Official Synonym Symbols
TNKL; ARTD6; TANK2; pART6; PARP5B; PARP5C; PARP-5b; PARP-5c
NCBI Protein Information
tankyrase-2; ADP-ribosyltransferase diphtheria toxin-like 6; TNKS-2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; poly [ADP-ribose] polymerase 5B; tankyrase 2; tankyrase II; tankyrase-like protein; tankyrase-related protein
UniProt Protein Name
Tankyrase-2
Protein Family
UniProt Gene Name
TNKS2
UniProt Synonym Gene Names
PARP5B; TANK2; TNKL; TANK2; ARTD6
UniProt Entry Name
TNKS2_HUMAN
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Product Notes
The TNKS2 tnks2 (Catalog #AAA9630650) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TNKS2 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's TNKS2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the TNKS2 tnks2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TNKS2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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