Rabbit anti-Human TNKS1BP1 Polyclonal Antibody | anti-TNKS1BP1 antibody

TNKS1BP1, ID (TNKS1BP1, KIAA1741, TAB182, 182kD tankyrase-1-binding protein) (PE)

Cat. Num. AAA6357185

• Gene Names: TNKS1BP1; TAB182
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TNKS1BP1; Polyclonal Antibody; ID (TNKS1BP1; KIAA1741; TAB182; 182kD tankyrase-1-binding protein) (PE); 182kD tankyrase-1-binding protein; anti-TNKS1BP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-TNKS1BP1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TNKS1BP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 928-955 amino acids from the Central region of human TNKS1BP1.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(TNKS1BP1 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TNKS1BP1 antibody detected the TNKS1BP1 protein (arrow).)

Related Product Information for anti-TNKS1BP1 antibody

Tankyrase binding protein 1 binds to the ANK repeat domain of TNKS1 and TNKS2. There are 2 named isoforms produced by alternative splicing.

Product Categories/Family for anti-TNKS1BP1 antibody

Antibodies; Binding Proteins

References

Miyasaka, T., et al. Cancer Sci. 99(4):755-761(2008). Morita, M., et al. Mol. Cell. Biol. 27(13):4980-4990(2007). Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007). Matsuoka, S., et al. Science 316(5828):1160-1166(2007). Gelmini, S., et al. Clin. Chem. Lab. Med. 45(7):862-866(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 110556636
• NCBI GeneID: 85456
• NCBI Accession #: NP_203754.2
• NCBI GenBank Nucleotide #: NM_033396.2
• UniProt Accession #: Q9C0C2; Q6PJ35; Q6ZV74; A7E2F8
• Molecular Weight: 181,796 Da
• NCBI Official Full Name: 182 kDa tankyrase-1-binding protein
• NCBI Official Synonym Full Names: tankyrase 1 binding protein 1, 182kDa
• NCBI Official Symbol: TNKS1BP1
• NCBI Official Synonym Symbols: TAB182
• NCBI Protein Information: 182 kDa tankyrase-1-binding protein; tankyrase 1-binding protein of 182 kDa
• UniProt Protein Name: 182 kDa tankyrase-1-binding protein
• Protein Family: 182 kDa tankyrase-1-binding protein
• UniProt Gene Name: TNKS1BP1
• UniProt Synonym Gene Names: KIAA1741; TAB182
• UniProt Entry Name: TB182_HUMAN

Uniprot Description

TNKS1BP1: 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Cell cycle regulation

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: nucleoplasm; cytoskeleton; cytoplasm; nuclear telomeric heterochromatin; plasma membrane; cytosol; nucleus; CCR4-NOT complex

Molecular Function: enzyme binding; ankyrin binding

Biological Process: poly(A) tail shortening; gene expression; telomere maintenance via telomerase; mRNA catabolic process, deadenylation-dependent decay