Rabbit TMPRSS4 Polyclonal Antibody | anti-TMPRSS4 antibody

Rabbit Polyclonal to Human TMPRSS4

Cat. Num. AAA243491

• Gene Names: TMPRSS4; CAPH2; MT-SP2; TMPRSS3
• Reactivity: Gibbon, Chimpanzee, Human, Monkey; Predicted Reactivity: Gorilla, Orangutan (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: TMPRSS4; Polyclonal Antibody; Rabbit Polyclonal to Human TMPRSS4; Anti-TMPRSS4 Antibody (Internal) IHC-plus; CAPH2; Channel-activating protease 2; MT-SP2; Human TMPRSS4; anti-TMPRSS4 antibody

• Host: Rabbit
• Reactivity: Gibbon, Chimpanzee, Human, Monkey; Predicted Reactivity: Gorilla, Orangutan (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human TMPRSS4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 437

• Applicable Applications for anti-TMPRSS4 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (5 ug/ml); Usage: Antigen retrieval with HIER and sodium citrate at pH 6.0 is required for Immunohistochemistry using formalin-fixed paraffin-embedded human tissues.
• Target Species: Human
• Immunogen Description: Synthetic 19 amino acid peptide from internal region of human TMPRSS4. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gibbon, Monkey, Marmoset (100%); Gorilla, Orangutan (95%); Dog, Horse (89%).
• Immunogen Type: Synthetic peptide
• Immunogen: TMPRSS4 antibody was raised against synthetic 19 amino acid peptide from internal region of human TMPRSS4. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gibbon, Monkey, Marmoset (100%); Gorilla, Orangutan (95%); Dog, Horse (89%); Hamster, Elephant, Panda, Pig (84%).
• Antigen Modification: Internal
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-TMPRSS4 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-TMPRSS4 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Product Categories/Family for anti-TMPRSS4 antibody

Family: Protease; Subfamily: Serine S1

NCBI and Uniprot Product Information

• NCBI GI #: 15451940
• NCBI GeneID: 56649
• NCBI Accession #: NP_063947.1
• NCBI GenBank Nucleotide #: NM_019894.3
• UniProt Accession #: Q9NRS4; Q5XKQ6; Q6UX37; Q9NZA5; A8MU84; B0YJB0; B7Z8C5; E7ERX8
• Molecular Weight: 43,786 Da
• NCBI Official Full Name: transmembrane protease serine 4 isoform 1
• NCBI Official Synonym Full Names: transmembrane protease, serine 4
• NCBI Official Symbol: TMPRSS4
• NCBI Official Synonym Symbols: CAPH2; MT-SP2; TMPRSS3
• NCBI Protein Information: transmembrane protease serine 4; channel-activating protease 2; membrane-type serine protease 2; transmembrane serine protease 3; type II membrane serine protease
• UniProt Protein Name: Transmembrane protease serine 4
• Protein Family: Transmembrane protease serine
• UniProt Gene Name: TMPRSS4
• UniProt Synonym Gene Names: TMPRSS3; CAPH2; MT-SP2
• UniProt Entry Name: TMPS4_HUMAN

NCBI Description

This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

TMPRSS4: Probable protease. Seems to be capable of activating ENaC. Belongs to the peptidase S1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Protease; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: integral to membrane

Molecular Function: serine-type endopeptidase activity; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; proteolysis