Rabbit anti-Human TMED6 Polyclonal Antibody | anti-TMED6 antibody

TMED6, ID (TMED6, Transmembrane emp24 domain-containing protein 6, p24 family protein gamma-5) (Biotin)

Cat. Num. AAA6356264

• Gene Names: TMED6; PRO34237; SPLL9146
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TMED6; Polyclonal Antibody; ID (TMED6; Transmembrane emp24 domain-containing protein 6; p24 family protein gamma-5) (Biotin); p24 family protein gamma-5; anti-TMED6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-TMED6 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TMED6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-153 amino acids from the Central region of human TMED6.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(TMED6 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the TMED6 antibody detected the TMED6 protein (arrow).)

Related Product Information for anti-TMED6 antibody

TMED6 (transmembrane emp24 domain-containing protein 6) is a 240 amino acid single-pass type I membrane protein that belongs to the EMP24/GP25L family and contains one GOLD domain. The gene that encodes TMED6 contains around 8,564 bases and maps to human chromosome 16q22.1. Encoding over 900 genes and consisting of approximately 90 million base pairs, chromosome 16 makes up nearly 3% of the human genome and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, when mutated, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. Alterations in the CREB gene and NOD2 gene, both of which are located on chromosome 16, result in Rubinstein-Taybi syndrome and Crohn's disease, respectively. An association with systemic lupus erythematosis and a number of other autoimmune disorders with the pericentromeric region of chromosome 16 has led to the identification of SLC5A11 as a potential autoimmune modifier.

Product Categories/Family for anti-TMED6 antibody

Antibodies; Membrane Proteins

References

Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 269914167
• NCBI GeneID: 146456
• NCBI Accession #: NP_653277.2
• NCBI GenBank Nucleotide #: NM_144676.3
• UniProt Accession #: Q8WW62; Q6UXN5
• Molecular Weight: 27,631 Da
• NCBI Official Full Name: transmembrane emp24 domain-containing protein 6
• NCBI Official Synonym Full Names: transmembrane emp24 protein transport domain containing 6
• NCBI Official Symbol: TMED6
• NCBI Official Synonym Symbols: PRO34237; SPLL9146
• NCBI Protein Information: transmembrane emp24 domain-containing protein 6; p24gamma5; p24 family protein gamma-5
• UniProt Protein Name: Transmembrane emp24 domain-containing protein 6
• Protein Family: Transmembrane emp24 domain-containing protein
• UniProt Gene Name: TMED6
• UniProt Synonym Gene Names: UNQ9146/PRO34237; p24gamma5
• UniProt Entry Name: TMED6_HUMAN