Western Blot (WB)
(TMED2 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the TMED2 antibody detected the TMED2 protein (arrow).)
Rabbit TMED2 Polyclonal Antibody | anti-TMED2 antibody
TMED2 Antibody (N-term)
Western Blot (WB)
(TMED2 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the TMED2 antibody detected the TMED2 protein (arrow).)
Western Blot (WB)
(TMED2 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the TMED2 antibody detected the TMED2 protein (arrow).)
Immunohistochemistry (IHC)
(TMED2 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TMED2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(TMED2 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TMED2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Luo, W., et al. J. Biol. Chem. 282(41):30246-30255(2007)
Chen, F., et al. Nature 440(7088):1208-1212(2006)
Breuza, L., et al. J. Biol. Chem. 279(45):47242-47253(2004)
Barr, F.A., et al. J. Cell Biol. 155(6):885-891(2001)
NCBI and Uniprot Product Information
Uniprot Description
TMED2: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase- activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing. Belongs to the EMP24/GP25L family.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: COPI coated vesicle membrane; Golgi apparatus; COPI-coated vesicle; endoplasmic reticulum membrane; zymogen granule membrane; ER-Golgi intermediate compartment membrane; intracellular membrane-bound organelle; endoplasmic reticulum; ER-Golgi intermediate compartment; integral to membrane
Molecular Function: protein binding
Biological Process: COPII coating of Golgi vesicle; intracellular protein transport; ER to Golgi vesicle-mediated transport; COPI coating of Golgi vesicle; embryonic morphogenesis; Golgi organization and biogenesis; maternal placenta development
Research Articles on TMED2
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Product Notes
The TMED2 tmed2 (Catalog #AAA9202834) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 50-79. The TMED2 Antibody (N-term) reacts with Human (Predicted Reactivity: Hamster, Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's TMED2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the TMED2 tmed2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TMED2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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