Rabbit TMED2 Polyclonal Antibody | anti-TMED2 antibody

TMED2 Antibody

Cat. Num. AAA9630150

• Gene Names: TMED2; p24; P24A; RNP24
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: TMED2; Polyclonal Antibody; TMED2 Antibody; coated vesicle membrane protein; Membrane protein p24A; p24; p24 family protein beta-1; P24A; p24beta1; RNP24; Sid 394; Sid394; TMED2_HUMAN; transmembrane emp24 domain trafficking protein 2; Transmembrane emp24 domain-containing protein 2; anti-TMED2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: TMED2 Antibody detects endogenous levels of TMED2.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-TMED2 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human TMED2.
• Conjugation: Unconjugated
• Similarity: Belongs to the EMP24/GP25L family.
• Subunit Structure: Monomer and homodimer in the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and Golgi. Probably oligomerizes with other members of the EMP24/GP25L family such as TMED7, TMED9 and TMED10. Interacts (via GOLD domain) with TMED10 (via GOLD domain). Associates with the COPI vesicle coat (coatomer); TMED10:TMED2 heterotetramers are proposed to be involved in coatomer association. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED2. Interacts with SEC23A; indicative for an association of TMED2 with the COPII vesicle coat. Interacts with ARF1 and ARFGAP1 (By similarity). Interacts with CD59, SEC24A, SEC24B, SEC24C, SEC24D and ATLA1. Interacts with KDELR1; the interaction is decreased by KDEL ligand (By similarity). Interacts with F2RL1; the interaction occurs at the Golgi apparatus. Interacts with CASR (immaturely glycosylated form); the interaction occurs in the endoplasmic reticulum-Golgi intermediate compartment or cis-Golgi. Interacts with F2RL1; the interaction occurs at the Golgi apparatus. Interacts with GORASP1 and GORASP2 (By similarity). Found in a complex composed at least of SURF4, TMED2 and TMED10.
• Function: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.
• Note: Cycles between compartments of the early secretatory pathway.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-TMED2 antibody

Cytoplasmic vesicle membrane; Single-pass type I membrane protein; Cytoplasmic vesicle; COPI-coated vesicle membrane; Golgi apparatus; cis-Golgi network membrane; Golgi stack membrane; Endoplasmic reticulum membrane; Endoplasmic reticulum-Golgi intermedia

NCBI and Uniprot Product Information

• NCBI GI #: 5803149
• NCBI GeneID: 10959
• NCBI Accession #: NP_006806.1
• NCBI GenBank Nucleotide #: NM_006815.3
• UniProt Accession #: Q15363
• Molecular Weight: 22,761 Da
• NCBI Official Full Name: transmembrane emp24 domain-containing protein 2
• NCBI Official Synonym Full Names: transmembrane emp24 domain trafficking protein 2
• NCBI Official Symbol: TMED2
• NCBI Official Synonym Symbols: p24; P24A; RNP24
• NCBI Protein Information: transmembrane emp24 domain-containing protein 2; p24beta1; membrane protein p24A; p24 family protein beta-1; coated vesicle membrane protein
• UniProt Protein Name: Transmembrane emp24 domain-containing protein 2
• Protein Family: Transmembrane emp24 domain-containing protein
• UniProt Gene Name: TMED2
• UniProt Synonym Gene Names: RNP24; p24beta1
• UniProt Entry Name: TMED2_HUMAN