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Immunohistochemistry (IHC) (Anti-TLX2 / NCX antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Rabbit TLX2 / NCX Polyclonal Antibody | anti-TLX2 / NCX antibody

Anti-TLX2 / NCX Antibody (N-Terminus) IHC-plus

Gene Names
TLX2; NCX; HOX11L1
Reactivity
Mouse, Rat, Human
Applications
Immunohistochemistry, Immunofluorescence, Western Blot, ELISA
Purity
Immunoaffinity purified
Synonyms
TLX2 / NCX; Polyclonal Antibody; Anti-TLX2 / NCX Antibody (N-Terminus) IHC-plus; Rabbit Polyclonal (IgG) to Human TLX2 / NCX; Human TLX2 / NCX; Enx; Homeobox protein Hox-11L1; Neural crest homeobox protein; Homeo box 11-like 1; T-cell leukemia homeobox 2; HOX11L1; T-cell leukemia; homeobox 2; anti-TLX2 / NCX antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Mouse, Rat, Human
Clonality
Polyclonal
Isotype
IgG
Specificity
TLX2 antibody is predicted to not cross-react with other TLX proteins.
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.02% sodium azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
284
Applicable Applications for anti-TLX2 / NCX antibody
Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes
IF (20 ug/ml)
IHC-P (10 ug/ml)
WB (0.5 - 1 ug/ml)
Immunogen
TLX2 / NCX antibody was raised against 18 amino acid peptide near the amino terminus of human TLX2.
Immunogen Description
18 amino acid peptide near the amino terminus of human TLX2.
Antigen Modification
N-Terminus
Target Species
Human
Preparation and Storage
Long term: -20 degree C
Short term: 4 degree C
Avoid repeat freeze-thaw cycles

Immunohistochemistry (IHC)

(Anti-TLX2 / NCX antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Immunohistochemistry (IHC) (Anti-TLX2 / NCX antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Immunofluorescence (IF)

(Immunofluorescence of TLX2 in rat brain tissue with TLX2 antibody at 20 ug/ml.)

Immunofluorescence (IF) (Immunofluorescence of TLX2 in rat brain tissue with TLX2 antibody at 20 ug/ml.)

Western Blot (WB)

(Western blot analysis of TLX2 in rat brain tissue lysate with TLX2 antibody at (A) 0.5 and (B) 1 ug/ml.)

Western Blot (WB) (Western blot analysis of TLX2 in rat brain tissue lysate with TLX2 antibody at (A) 0.5 and (B) 1 ug/ml.)
Related Product Information for anti-TLX2 / NCX antibody
TLX2 Antibody, Enx Antibody, Homeobox protein Hox-11L1 Antibody, Neural crest homeobox protein Antibody, Homeo box 11-like 1 Antibody, T-cell leukemia homeobox 2 Antibody, NCX Antibody, HOX11L1 Antibody, T-cell leukemia, homeobox 2 Antibody Description: Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
30,251 Da
NCBI Official Full Name
T-cell leukemia homeobox protein 2
NCBI Official Synonym Full Names
T-cell leukemia homeobox 2
NCBI Official Symbol
TLX2
NCBI Official Synonym Symbols
NCX; HOX11L1
NCBI Protein Information
T-cell leukemia homeobox protein 2
UniProt Protein Name
T-cell leukemia homeobox protein 2
UniProt Gene Name
TLX2
UniProt Synonym Gene Names
HOX11L1; NCX
UniProt Entry Name
TLX2_HUMAN

NCBI Description

This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors. [provided by RefSeq, May 2010]

Uniprot Description

TLX2: Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract.

Protein type: Cell development/differentiation; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: cytoplasm; nucleus

Molecular Function: sequence-specific DNA binding

Biological Process: enteric nervous system development; mesoderm formation; negative regulation of dendrite morphogenesis; regulation of transcription, DNA-dependent; transcription, DNA-dependent

Research Articles on TLX2 / NCX

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Product Notes

The TLX2 / NCX tlx2 (Catalog #AAA249748) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-TLX2 / NCX Antibody (N-Terminus) IHC-plus reacts with Mouse, Rat, Human and may cross-react with other species as described in the data sheet. AAA Biotech's TLX2 / NCX can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), Western Blot (WB), ELISA (EIA). IF (20 ug/ml) IHC-P (10 ug/ml) WB (0.5 - 1 ug/ml). Researchers should empirically determine the suitability of the TLX2 / NCX tlx2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TLX2 / NCX, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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