Western Blot (WB)
(TLR7 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the TLR7 antibody detected the TLR7 protein (arrow).)
Rabbit TLR7 Polyclonal Antibody | anti-TLR7 antibody
TLR7 Antibody (C-term)
Western Blot (WB)
(TLR7 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the TLR7 antibody detected the TLR7 protein (arrow).)
Western Blot (WB)
(TLR7 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the TLR7 antibody detected the TLR7 protein (arrow).)
Toll-like receptor (TLR) family which plays a fundamental role in
pathogen recognition and activation of innate immunity. TLRs are
highly conserved from Drosophila to humans and share structural and
functional similarities. They recognize pathogen-associated
molecular patterns (PAMPs) that are expressed on infectious agents,
and mediate the production of cytokines necessary for the
development of effective immunity. The various TLRs exhibit
different patterns of expression. This gene is predominantly
expressed in lung, placenta, and spleen, and lies in close
proximity to another family member, TLR8, on chromosome X.
Manuse, M.J., et al. Virology 405(2):383-389(2010)
Cros, J., et al. Immunity 33(3):375-386(2010)
Shen, N., et al. Proc. Natl. Acad. Sci. U.S.A. 107(36):15838-15843(2010)
Enevold, C., et al. Mult. Scler. 16(8):942-949(2010)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008]
Uniprot Description
TLR7: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1. Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. Belongs to the Toll-like receptor family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: Xp22.3
Cellular Component: Golgi membrane; endoplasmic reticulum membrane; endoplasmic reticulum; lysosome; cytoplasm; plasma membrane; integral to membrane; endosome membrane; receptor complex; endosome
Molecular Function: siRNA binding; single-stranded RNA binding; transmembrane receptor activity; double-stranded RNA binding; drug binding
Biological Process: positive regulation of interleukin-6 production; microglial cell activation; positive regulation of interleukin-8 biosynthetic process; positive regulation of NF-kappaB import into nucleus; positive regulation of interferon-alpha biosynthetic process; toll-like receptor 7 signaling pathway; positive regulation of chemokine production; positive regulation of interleukin-8 production; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interferon-beta biosynthetic process; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; I-kappaB phosphorylation; inflammatory response; defense response to virus; positive regulation of inflammatory response; positive regulation of interferon-gamma biosynthetic process
Research Articles on TLR7
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Product Notes
The TLR7 tlr7 (Catalog #AAA9210385) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 899-926. The TLR7 Antibody (C-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's TLR7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the TLR7 tlr7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TLR7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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