Sheep Tissue Factor Pathway Inhibitor Polyclonal Antibody | anti-TFPI antibody

Sheep anti-human Tissue Factor Pathway Inhibitor (TFPI), Purified IgG

Cat. Num. AAA512162

• Gene Names: TFPI; EPI; TFI; LACI; TFPI1
• Purity: Purified IgG
• Synonyms: Tissue Factor Pathway Inhibitor; Polyclonal Antibody; Sheep anti-human Tissue Factor Pathway Inhibitor (TFPI); Purified IgG; human; anti-TFPI antibody

• Host: Sheep
• Clonality: Polyclonal
• Specificity: This antibody is specific for TFPI as demonstrated by immunoelectrophoresis and ELISA.
• Purity/Purification: Purified IgG

• Application Notes: This product is suitable as a source of antibodies to TFPI.
• Immunogen: Synthetic peptide corresponding to NH-terminus of human TFPI conjugated to carrier.
• Presentation: XXXX ml of immunoglobulin purified from sheep antiserum. The IgG concentration is XXXX mg/ml in 10 mM HEPES, pH 7.4, containing 0.15 M NaCl and 50% glycerol (v/v). Total protein is 10 mg.
• Preparation and Storage: Store between -10 and -20 degree C. Product will become viscous but will not freeze. Avoid storage in frost-free freezers. Keep vial tightly capped. Allow product to warm to room temperature and gently mix before use.

NCBI and Uniprot Product Information

• NCBI GI #: 125932
• NCBI GeneID: 7035
• NCBI Accession #: P10646.1
• NCBI GenBank Nucleotide #: P10646
• UniProt Accession #: P10646; O95103; Q53TS4; Q59EE5
• Molecular Weight: 35,015 Da
• NCBI Official Full Name: Tissue factor pathway inhibitor
• NCBI Official Synonym Full Names: tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
• NCBI Official Symbol: TFPI
• NCBI Official Synonym Symbols: EPI; TFI; LACI; TFPI1
• NCBI Protein Information: tissue factor pathway inhibitor; anti-convertin; OTTHUMP00000163472; OTTHUMP00000205424; OTTHUMP00000205430; OTTHUMP00000205431; extrinsic pathway inhibitor; lipoprotein-associated coagulation inhibitor
• UniProt Protein Name: Tissue factor pathway inhibitor
• Protein Family: Tissue factor pathway inhibitor
• UniProt Gene Name: TFPI
• UniProt Synonym Gene Names: LACI; TFPI1
• UniProt Entry Name: TFPI1_HUMAN

NCBI Description

This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq]

Uniprot Description

Function: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.

Subcellular location: Secreted.

Tissue specificity: Mostly in endothelial cells.

Domain: This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa.

Post-translational modification: O-glycosylated. Ref.10 Ref.14 Ref.16

Sequence similarities: Contains 3 BPTI/Kunitz inhibitor domains.