Rabbit tir-1 Polyclonal Antibody | anti-tir-1 antibody

Rabbit anti-Caenorhabditis elegans tir-1 Polyclonal Antibody

• Reactivity: Caenorhabditis elegans
• Applications: ELISA, Western Blot
• Purity: Protein A/G
• Synonyms: tir-1; Polyclonal Antibody; Rabbit anti-Caenorhabditis elegans tir-1 Polyclonal Antibody; tir-1 Antibody; Sterile alpha and TIR motif-containing protein tir-1; Neuronal symmetry protein 2; SARM1 homolog; tir-1 nsy-2 F13B10.1; anti-tir-1 antibody

• Host: Rabbit
• Reactivity: Caenorhabditis elegans
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Protein A/G
• Form/Format: Liquid; Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, pH7.4

• Applicable Applications for anti-tir-1 antibody: ELISA (EIA), WB (Western Blot) (ensure identification of antigen)
• Immunogen: Recombinant Caenorhabditis elegans tir-1 protein
• Conjugation: Non-conjugate
• Modification: Unmodified
• Deliverables: 1. 200ug recombinant immunogen protein/peptide (positive control).; 2. 1mL preimmune serum (negative control); 3. 10mg rabbit polyclonal antibody purified by Protein A/G.
• Quality Guarantee: 1. Antibody purity >90% confirmed by SDS-PAGE.; 2. Antibody titer > 1: 64,000 confirmed by ELISA; 3. Western Blot positive for the immunogen protein (Not applicable for synthetic peptide).
• Complementary Antibody: Customer can choose 1 FREE antibody from the list below. Please specify the catalog # when order:; * 6*His Monoclonal Antibody #MBS1491670; * DYKDDDDK tag Monoclonal Antibody #MBS1493946; * GAPDH Monoclonal Antibody #MBS1495524; * GFP Monoclonal Antibody #MBS1496050; * Myc tag Monoclonal Antibody #MBS1497694; * GST Monoclonal Antibody #MBS1497871; * Sumo tag Monoclonal Antibody #MBS1498878; * Goat Anti-Rabbit IgG (H+L) Antibody; HRP conjugated #MBS7053510; * HA-Tag Monoclonal Antibody #MBS7135631; * E-Tag Monoclonal Antibody #MBS7135632; * TUBA1A Monoclonal Antibody #MBS7135645; * TUBB Monoclonal Antibody #MBS9018332
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

NCBI and Uniprot Product Information

• NCBI GI #: 922580221
• NCBI GeneID: 175502
• NCBI Accession #: NP_001021251.2
• NCBI GenBank Nucleotide #: NM_001026080.3
• UniProt Accession #: Q86DA5; O17801; O17802; Q19373; Q7JMF4; Q7JMF5
• Molecular Weight: 90,971 Da
• NCBI Official Full Name: Sterile alpha and TIR motif-containing protein tir-1
• NCBI Official Symbol: tir-1
• NCBI Protein Information: Sterile alpha and TIR motif-containing protein tir-1; TIR (Toll and Interleukin 1 Receptor) domain protein
• UniProt Protein Name: Sterile alpha and TIR motif-containing protein tir-1
• Protein Family: Sterile alpha and TIR motif-containing protein
• UniProt Gene Name: tir-1
• UniProt Synonym Gene Names: nsy-2

Uniprot Description

Required for both innate immune response and specification of AWC(OFF) neuron (PubMed:15048112, PubMed:15123841, PubMed:15625192). During late embryogenesis, it. acts downstream of CAMKII (unc-43) to regulate specification of asymmetric odorant receptors in AWC(OFF) neuron via the nsy-1/ASK1 pmk-1/p38 MAP kinase signaling cascade. Required to localize nsy-1 to postsynaptic regions of AWC neuron, suggesting that it may act by assembling a signaling complex that regulate odorant receptor expression (PubMed:15625192). Also plays a central role in resistance to infection to a broad range of bacterial and fungi pathogens, possibly by activating pmk-1, independently of the NF-kappa-B pathway. Required for expression of antimicrobial peptides nlp-29 and nlp-31 (PubMed:15048112, PubMed:15123841). Its role in immune response and neuron specification may be mediated by the same nsy-1/ASK1 pmk-1/p38 MAP kinase cascade signaling pathway (PubMed:15048112, PubMed:15123841, PubMed:15625192). Involved in the response to anoxic conditions probably by activating the p38 pathway composed of nsy-1/sek-1/pmk-1 (PubMed:21212236). In males, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development (PubMed:22363008).