Goat TIM-3 Polyclonal Antibody | anti-TIM-3 antibody

GOAT ANTI HUMAN TIM-3

Cat. Num. AAA224005

• Gene Names: HAVCR2; TIM3; KIM-3; TIMD3; Tim-3; TIMD-3; HAVcr-2
• Reactivity: Dog (Expected from Sequence)
• Applications: ELISA, Western Blot
• Synonyms: TIM-3; Polyclonal Antibody; GOAT ANTI HUMAN TIM-3; anti-TIM-3 antibody

• Host: Goat
• Reactivity: Dog (Expected from Sequence)
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: This item specifically recognises human TIM-3 (T-cell immunoglobulin mucin-3), a Th1-specific transmembrane protein and member of the immunoglobulin superfamily, which acts as a regulator of macrophage activation, and an inhibitor of Th1-mediated auto- and alloimmune responses.
• Form/Format: Purified; Purified IgG - liquid
• Concentration: IgG concentration 0.5mg/ml (varies by lot)
• Sequence Length: 301

• Applicable Applications for anti-TIM-3 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: Western Blot: This item detects a band of approximately 35kDa in human tonsil, spleen, lymph node and thymus cell lysates ; ELISA: Maximum Dilution: 1/32000; Western Blotting: Minimum Dilution: 0.3; Maximum Dilution: 1.0ug/ml
• Perservative Stabilisers: 0.02% Sodium Azide (NaN3); 0.5% Bovine Serum Albumin
• Immunogen: Synthetic peptide sequence C-KWYSHSKEKIQN from the internal region of TIM-3 (NP_116171.3); Buffer Solution
• Antiserum Preparation: Antiserum to human TIM-3 was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
• Target Species: Human
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Related Product Information for anti-TIM-3 antibody

MBS224005 specifically recognises human TIM-3 (T-cell immunoglobulin mucin-3), a Th1-specific transmembrane protein and member of the immunoglobulin superfamily, which acts as a regulator of macrophage activation, and an inhibitor of Th1-mediated auto- and alloimmune responses.

NCBI and Uniprot Product Information

• NCBI GI #: 49574534
• NCBI GeneID: 84868
• NCBI Accession #: NP_116171.3
• NCBI GenBank Nucleotide #: NM_032782.4
• UniProt Accession #: Q8TDQ0; Q8WW60; Q96K94; B2RAY2
• Molecular Weight: 16,149 Da
• NCBI Official Full Name: hepatitis A virus cellular receptor 2
• NCBI Official Synonym Full Names: hepatitis A virus cellular receptor 2
• NCBI Official Symbol: HAVCR2
• NCBI Official Synonym Symbols: TIM3; KIM-3; TIMD3; Tim-3; TIMD-3; HAVcr-2
• NCBI Protein Information: hepatitis A virus cellular receptor 2; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; kidney injury molecule-3
• UniProt Protein Name: Hepatitis A virus cellular receptor 2
• UniProt Gene Name: HAVCR2
• UniProt Synonym Gene Names: TIM3; TIMD3; HAVcr-2; TIMD-3; TIM-3
• UniProt Entry Name: HAVR2_HUMAN

NCBI Description

The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]

Uniprot Description

TIM-3: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. Belongs to the immunoglobulin superfamily. TIM family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q33.3

Cellular Component: integral to membrane

Disease: Rheumatoid Arthritis