Rabbit anti-Human TIAM1 Polyclonal Antibody | anti-TIAM1 antibody

TIAM1 Polyclonal Antibody

Cat. Num. AAA2564583

• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Affinity purification
• Synonyms: TIAM1; Polyclonal Antibody; TIAM1 Polyclonal Antibody; anti-TIAM1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: 1mg/mL (varies by lot)

• Applicable Applications for anti-TIAM1 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Recombinant fusion protein of human TIAM1 (NP_0032442)
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human lung cancer using TIAM1 Polyclonal Antibody at dilution of 1:100 (40x lens).)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colon carcinoma using TIAM1 Polyclonal Antibody at dilution of 1:100 (40x lens).)

Related Product Information for anti-TIAM1 antibody

This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain.

Product Categories/Family for anti-TIAM1 antibody

Polyclonal Antibody

NCBI and Uniprot Product Information

• NCBI GI #: 115583670
• NCBI GeneID: 7074
• NCBI Accession #: NP_003244.2
• NCBI GenBank Nucleotide #: NM_003253.2
• UniProt Accession #: Q13009; Q17RT7; B7ZLR6; F5GZ53
• Molecular Weight: 170,580 Da
• NCBI Official Full Name: T-lymphoma invasion and metastasis-inducing protein 1
• NCBI Official Synonym Full Names: T-cell lymphoma invasion and metastasis 1
• NCBI Official Symbol: TIAM1
• NCBI Protein Information: T-lymphoma invasion and metastasis-inducing protein 1
• UniProt Protein Name: T-lymphoma invasion and metastasis-inducing protein 1
• Protein Family: T-lymphoma invasion and metastasis-inducing protein
• UniProt Gene Name: TIAM1
• UniProt Synonym Gene Names: TIAM-1

Uniprot Description

TIAM1: modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Regulates migration, cell-matrix and cell-cell adhesion by modulating the actin cytoskeleton through the GTPase, Rac1. Binding to Rac1 and the Arp2/3 complex may drive actin polymerization at specific sites, thus inducing dynamic morphological changes.

Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: cytosol; extrinsic to internal side of plasma membrane; intercellular junction; plasma membrane

Molecular Function: guanyl-nucleotide exchange factor activity; kinase binding; protein binding; Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity

Biological Process: cell migration; cell-matrix adhesion; ephrin receptor signaling pathway; positive regulation of apoptosis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of protein binding; Rac protein signal transduction; regulation of small GTPase mediated signal transduction