Rabbit anti-Human Thyroxine Binding Globulin (TBG) Polyclonal Antibody | anti-TBG antibody

APC/CY7-Linked Polyclonal Antibody to Thyroxine Binding Globulin (TBG)

Cat. Num. AAA2040827

• Gene Names: SERPINA7; TBG; TBGQTL
• Reactivity: Human
• Applications: Western Blot, Immunocytochemistry, Immunohistochemistry, ELISA
• Synonyms: Thyroxine Binding Globulin (TBG); Polyclonal Antibody; APC/CY7-Linked Polyclonal Antibody to Thyroxine Binding Globulin (TBG); SERPINA7; Serpin Peptidase Inhibitor Clade A Member 7; T4-binding globulin; anti-TBG antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Concentration: >=100ug/ml (varies by lot)

• Applicable Applications for anti-TBG antibody: Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
• Immunogen: TBG (Leu128~Ala415)
• Conjugation: APC-Cy7
• Cross Reactivity: Human
• Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2005052

Knockout Validation

(Knockout Validation: Lane 1: Wild-type Hela cell lysate; Lane 2: TBG knockout Hela cell lysate; Predicted MW: 46kd Observed MW: 46kd Primary Ab: 5ug/ml Rabbit Anti-Human TBG Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))

NCBI and Uniprot Product Information

• NCBI GI #: 205277441
• NCBI GeneID: 6906
• NCBI Accession #: NP_000345.2
• NCBI GenBank Nucleotide #: NM_000354.5
• UniProt Accession #: P05543; D3DUX1
• Molecular Weight: 46,325 Da
• NCBI Official Full Name: thyroxine-binding globulin
• NCBI Official Synonym Full Names: serpin family A member 7
• NCBI Official Symbol: SERPINA7
• NCBI Official Synonym Symbols: TBG; TBGQTL
• NCBI Protein Information: thyroxine-binding globulin
• UniProt Protein Name: Thyroxine-binding globulin
• UniProt Gene Name: SERPINA7
• UniProt Synonym Gene Names: TBG

NCBI Description

There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]

Uniprot Description

SERPINA7: Major thyroid hormone transport protein in serum. Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency). Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein- bound iodine but are euthyroid. Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: Xq22.3

Molecular Function: serine-type endopeptidase inhibitor activity

Disease: Thyroxine-binding Globulin Quantitative Trait Locus