Knockout Validation
(Knockout Validation: Lane 1: Wild-type 293T cell lysate;;Lane 2: TK1 knockout 293T cell lysate;;Predicted MW: 25kDaa ;Observed MW: 26kDa;Primary Ab: 3ug/ml Rabbit Anti-Human TK1 Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;(#MBS2086047))
Rabbit anti-Human Thymidine Kinase 1, Soluble (TK1) Polyclonal Antibody | anti-TK1 antibody
Cy3-Linked Polyclonal Antibody to Thymidine Kinase 1, Soluble (TK1)
Knockout Validation
(Knockout Validation: Lane 1: Wild-type 293T cell lysate;;Lane 2: TK1 knockout 293T cell lysate;;Predicted MW: 25kDaa ;Observed MW: 26kDa;Primary Ab: 3ug/ml Rabbit Anti-Human TK1 Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;(#MBS2086047))
Knockout Validation
(Knockout Validation: Lane 1: Wild-type 293T cell lysate;;Lane 2: TK1 knockout 293T cell lysate;;Predicted MW: 25kDaa ;Observed MW: 26kDa;Primary Ab: 3ug/ml Rabbit Anti-Human TK1 Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;(#MBS2086047))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. [provided by RefSeq, Oct 2016]
Uniprot Description
TK: cytosolic thymidine kinase. Phosphorylated during mitosis. Its enzymatic activity is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.
Protein type: EC 2.7.1.21; Kinase, other; Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: cytosol
Molecular Function: identical protein binding; nucleoside kinase activity; protein binding; zinc ion binding
Biological Process: DNA metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; protein homotetramerization; pyrimidine nucleoside salvage; thymidine metabolic process
Research Articles on TK1
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Product Notes
The TK1 tk1 (Catalog #AAA2068384) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cy3-Linked Polyclonal Antibody to Thymidine Kinase 1, Soluble (TK1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Thymidine Kinase 1, Soluble (TK1) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA). Researchers should empirically determine the suitability of the TK1 tk1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Thymidine Kinase 1, Soluble (TK1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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