TGR5 Polyclonal Antibody | anti-TGR5 antibody

TGR5 Polyclonal Antibody

Cat. Num. AAA8525617

• Gene Names: GPBAR1; BG37; TGR5; M-BAR; GPCR19; GPR131
• Synonyms: TGR5; Polyclonal Antibody; TGR5 Polyclonal Antibody; anti-TGR5 antibody

• Clonality: Polyclonal
• Sequence Length: 330

NCBI and Uniprot Product Information

• NCBI GI #: 116284384
• NCBI GeneID: 151306
• NCBI Accession #: NP_001070659.1
• NCBI GenBank Nucleotide #: NM_001077191.1
• UniProt Accession #: Q8TDU6; B3KV35
• Molecular Weight: 35,248 Da
• NCBI Official Full Name: G-protein coupled bile acid receptor 1
• NCBI Official Synonym Full Names: G protein-coupled bile acid receptor 1
• NCBI Official Symbol: GPBAR1
• NCBI Official Synonym Symbols: BG37; TGR5; M-BAR; GPCR19; GPR131
• NCBI Protein Information: G-protein coupled bile acid receptor 1
• UniProt Protein Name: G-protein coupled bile acid receptor 1
• UniProt Gene Name: GPBAR1
• UniProt Synonym Gene Names: TGR5; hGPCR19; M-BAR; BG37

NCBI Description

This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Uniprot Description

Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.