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Immunohistochemistry (IHC) (Anti-TG737 / IFT88 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Rabbit anti-Mouse, Human TG737 / IFT88 Polyclonal Antibody | anti-TG737 / IFT88 antibody

Anti-TG737 / IFT88 Antibody (aa798-827) IHC-plus

Gene Names
IFT88; DAF19; TG737; TTC10; hTg737; D13S1056E
Reactivity
Mouse, Human
Applications
Immunohistochemistry, Immunofluorescence, Western Blot
Purity
Immunoaffinity purified
Synonyms
TG737 / IFT88; Polyclonal Antibody; Anti-TG737 / IFT88 Antibody (aa798-827) IHC-plus; Rabbit Polyclonal to Human TG737 / IFT88; Human TG737 / IFT88; DAF19; D13S1056E; HTg737; RP11-172H24.2; Polaris homolog; TPR repeat protein 10; TTC10; anti-TG737 / IFT88 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Mouse, Human
Clonality
Polyclonal
Specificity
Human TG737 / IFT88
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.09% sodium azide
Sequence Length
824
Applicable Applications for anti-TG737 / IFT88 antibody
Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), Western Blot (WB)
Application Notes
IF (1:10 - 1:50)
IHC-P (1:10 - 1:100)
WB (1:1000)
Immunogen
TG737 / IFT88 antibody was raised against kLH-conjugated synthetic peptide from C-terminal region of human IFT88.
Immunogen Description
KLH-conjugated synthetic peptide from C-terminal region of human IFT88.
Immunogen Type
Synthetic peptide
Antigen Modification
aa798-827
Target Species
Human
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months.
For long term storage store at -20 degree C.

Immunohistochemistry (IHC)

(Anti-TG737 / IFT88 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-TG737 / IFT88 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunofluorescence (IF)

(Confocal immunofluorescence of IFT88 Antibody with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).)

Immunofluorescence (IF) (Confocal immunofluorescence of IFT88 Antibody with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).)

Western Blot (WB)

(IFT88 Antibody western blot of CEM cell line lysates (35 ug/lane). The IFT88 antibody detected the IFT88 protein (arrow).)

Western Blot (WB) (IFT88 Antibody western blot of CEM cell line lysates (35 ug/lane). The IFT88 antibody detected the IFT88 protein (arrow).)

Western Blot (WB)

(IFT88 Antibody western blot of mouse testis tissue lysates (35 ug/lane). The IFT88 antibody detected the IFT88 protein (arrow).)

Western Blot (WB) (IFT88 Antibody western blot of mouse testis tissue lysates (35 ug/lane). The IFT88 antibody detected the IFT88 protein (arrow).)
Related Product Information for anti-TG737 / IFT88 antibody
IFT88 Antibody, DAF19 Antibody, D13S1056E Antibody, HTg737 Antibody, RP11-172H24.2 Antibody, Polaris homolog Antibody, TPR repeat protein 10 Antibody, TTC10 Antibody, TG737 Antibody Description: Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
92,381 Da
NCBI Official Full Name
intraflagellar transport protein 88 homolog isoform 2
NCBI Official Synonym Full Names
intraflagellar transport 88
NCBI Official Symbol
IFT88
NCBI Official Synonym Symbols
DAF19; TG737; TTC10; hTg737; D13S1056E
NCBI Protein Information
intraflagellar transport protein 88 homolog
UniProt Protein Name
Intraflagellar transport protein 88 homolog
UniProt Gene Name
IFT88
UniProt Synonym Gene Names
TG737; TTC10; TPR repeat protein 10
UniProt Entry Name
IFT88_HUMAN

NCBI Description

This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

TTC10: Involved in primary cilium biogenesis. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 13q12.1

Cellular Component: acrosomal membrane; centriole; cilium; motile primary cilium; photoreceptor connecting cilium

Molecular Function: kinesin binding; protein binding

Biological Process: anterior/posterior pattern formation; cardiac muscle cell differentiation; cytoplasmic microtubule organization and biogenesis; determination of left/right symmetry; embryonic digit morphogenesis; epidermis development; eye development; forebrain morphogenesis; inner ear receptor stereocilium organization and biogenesis; kidney development; liver development; negative regulation of epithelial cell proliferation; Notch signaling pathway; organelle organization and biogenesis; palate development; pancreas development; positive regulation of insulin-like growth factor receptor signaling pathway; protein localization; regulation of fat cell differentiation; regulation of odontogenesis of dentine-containing teeth; regulation of smoothened signaling pathway; sensory cilium biogenesis; smoothened signaling pathway; sperm axoneme assembly; spermatid nuclear elongation; spinal cord dorsal/ventral patterning; telencephalon development

Research Articles on TG737 / IFT88

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Product Notes

The TG737 / IFT88 ift88 (Catalog #AAA2400019) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-TG737 / IFT88 Antibody (aa798-827) IHC-plus reacts with Mouse, Human and may cross-react with other species as described in the data sheet. AAA Biotech's TG737 / IFT88 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), Western Blot (WB). IF (1:10 - 1:50) IHC-P (1:10 - 1:100) WB (1:1000). Researchers should empirically determine the suitability of the TG737 / IFT88 ift88 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TG737 / IFT88, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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