Rabbit anti-Human TEX264 Polyclonal Antibody | anti-TEX264 antibody
TEX264 Antibody
Gene Names
TEX264; SIG11; ZSIG11; FLJ13935; DKFZp451H0417
Reactivity
Human
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
TEX264; Polyclonal Antibody; TEX264 Antibody; Putative secreted protein ZSIG11; Secreted protein ZSIG11; SIG11; TEG 264; testis expressed 264; testis expressed gene 264; Testis expressed sequence 264; Testis expressed sequence 264 protein; ZSIG11; anti-TEX264 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
TEX264 Antibody detects endogenous levels of TEX264.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-TEX264 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human TEX264.
Conjugation
Unconjugated
Similarity
The LIR motif in the cytosol-facing C-terminal region is involved in the interaction with ATG8 proteins. The long intrinsically disordered region (IDR) is required for autophagosome binding and reticulophagy, probably via bridging the long distance between endoplasmic reticulum and autophagosome membranes, because ribosomes exist on endoplasmic reticulum membranes that attach to autophagic membranes.
Subunit Structure
Interacts (via the LIR motif) with ATG8 family proteins MAP1LC3A, MAP1LC3B, GABARAP and GABARAPL1.
Function
Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins. Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure.
Note
Is trafficked from tubular ER to growing autophagosomes via its cytosolic LIR motif.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-TEX264 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
34,188 Da
NCBI Official Full Name
testis-expressed sequence 264 protein
NCBI Official Synonym Full Names
testis expressed 264
NCBI Official Symbol
TEX264
NCBI Official Synonym Symbols
SIG11; ZSIG11; FLJ13935; DKFZp451H0417
NCBI Protein Information
testis-expressed sequence 264 protein; OTTHUMP00000210973; OTTHUMP00000210974; OTTHUMP00000210975; OTTHUMP00000210976; testis expressed gene 264; testis expressed sequence 264; putative secreted protein ZSIG11
UniProt Protein Name
Testis-expressed sequence 264 protein
Protein Family
UniProt Gene Name
TEX264
UniProt Synonym Gene Names
ZSIG11; UNQ337/PRO536
UniProt Entry Name
TX264_HUMAN
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Product Notes
The TEX264 tex264 (Catalog #AAA9631225) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TEX264 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TEX264 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the TEX264 tex264 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TEX264, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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