Western Blot (WB)
(Western blot analysis of TTC5 in RAW264.7 cell lysate with TTC5 antibody at (A) 0.5ug/ml, (B) 1ug/ml and (C) 2ug/ml.)
Rabbit anti-Human, Mouse Tetratricopeptide Repeat Domain 5 Polyclonal Antibody | anti-TTC5 antibody
Tetratricopeptide Repeat Domain 5 (TTC5)
Gene Names
TTC5; Strap
Reactivity
Human, Mouse
Applications
Western Blot
Purity
Affinity PurifiedPurified by immunoaffinity chromatography.
Synonyms
Tetratricopeptide Repeat Domain 5; Polyclonal Antibody; Tetratricopeptide Repeat Domain 5 (TTC5); Anti -Tetratricopeptide Repeat Domain 5 (TTC5); anti-TTC5 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human. Species Crossreactivity: mouse.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
Applicable Applications for anti-TTC5 antibody
Western Blot (WB)
Application Notes
Suitable for use in Western Blot.
Dilution: Western Blot: 05-1ug/ml
Dilution: Western Blot: 05-1ug/ml
Immunogen
Synthetic peptide TTC5 14 aa near the carboxy terminus of human TTC5 (Genbank accession No. Q8N0Z6).
Positive Control
RAW264.7 cell lysate
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Western Blot (WB)
(Western blot analysis of TTC5 in RAW264.7 cell lysate with TTC5 antibody at (A) 0.5ug/ml, (B) 1ug/ml and (C) 2ug/ml.)
Western Blot (WB)
(Western blot analysis of TTC5 in RAW264.7 cell lysate with TTC5 antibody at (A) 0.5ug/ml, (B) 1ug/ml and (C) 2ug/ml.)
Related Product Information for anti-TTC5 antibody
Tetratricopeptide repeat protein 5 (TTC5) is a member of a diverse group of functionally distinct proteins that are characterized by containing one or more tetratricopeptide repeats (1). Each motif consists of two anti-parallel a-helices such that tandem arrays of TPR motifs generate a
right-handed helical structure with an amphipathic channel that may serve to accommodate the complementary region of a target protein. While the exact function of TTC5 remains unclear, it is thought that the TPR motifs serve to mediate protein-protein interactions such as those
seen with protein chaperones HSP70 and HSP90 (2) and some proteins involved in cell stress response signaling pathways such as protein phosphatase 5 (3), suggesting that TTC5 may also function via protein-protein interactions mediated by its TPR motifs.
right-handed helical structure with an amphipathic channel that may serve to accommodate the complementary region of a target protein. While the exact function of TTC5 remains unclear, it is thought that the TPR motifs serve to mediate protein-protein interactions such as those
seen with protein chaperones HSP70 and HSP90 (2) and some proteins involved in cell stress response signaling pathways such as protein phosphatase 5 (3), suggesting that TTC5 may also function via protein-protein interactions mediated by its TPR motifs.
Product Categories/Family for anti-TTC5 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
48,928 Da
NCBI Official Full Name
Tetratricopeptide repeat domain 5
NCBI Official Synonym Full Names
tetratricopeptide repeat domain 5
NCBI Official Symbol
TTC5
NCBI Official Synonym Symbols
Strap
NCBI Protein Information
tetratricopeptide repeat protein 5; OTTHUMP00000163990; OTTHUMP00000163991; TPR repeat protein 5
UniProt Protein Name
Tetratricopeptide repeat protein 5
Protein Family
UniProt Gene Name
TTC5
UniProt Entry Name
TTC5_HUMAN
Uniprot Description
TTC5: Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: nucleoplasm; cytoplasm
Molecular Function: DNA binding; chromatin binding
Biological Process: positive regulation of transcription from RNA polymerase II promoter; DNA repair
Research Articles on TTC5
Similar Products
Product Notes
The TTC5 ttc5 (Catalog #AAA615780) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Tetratricopeptide Repeat Domain 5 (TTC5) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Tetratricopeptide Repeat Domain 5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Dilution: Western Blot: 05-1ug/ml. Researchers should empirically determine the suitability of the TTC5 ttc5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Tetratricopeptide Repeat Domain 5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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