Rabbit anti-Human TES Polyclonal Antibody | anti-TES antibody

TES, NT (TES, Testin, TESS) (PE)

Cat. Num. AAA6354842

• Gene Names: TES; TESS; TESS-2
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TES; Polyclonal Antibody; NT (TES; Testin; TESS) (PE); TESS; anti-TES antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-TES antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TES antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-70 amino acids from the N-terminal region of human TES.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(TES Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the TES antibody detected the TES protein (arrow).)

Related Product Information for anti-TES antibody

Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. Multiple protein isoforms are encoded by transcript variants of this gene.

Product Categories/Family for anti-TES antibody

Antibodies; Transcription Factors

References

Qiu, H., et al. Cancer Sci. 101(5):1255-1260(2010). Gunduz, E., et al. Arch. Otolaryngol. Head Neck Surg. 135(3):254-260(2009). Zhong, Y., et al. Mol. Cell. Biochem. 320 (1-2), 85-92 (2009): Huang, W., et al. Ai Zheng 27(9):984-988(2008). Boeda, B., et al. Mol. Cell 28(6):1071-1082(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 23238188
• NCBI GeneID: 26136
• NCBI Accession #: NP_690042.1
• NCBI GenBank Nucleotide #: NM_152829.2
• UniProt Accession #: Q9UGI8; Q9GZQ1; Q9HAJ9; A4D0U6
• Molecular Weight: 50.1 kDa (441aa), confirmed by MALDI-TOF
• NCBI Official Full Name: testin isoform 2
• NCBI Official Synonym Full Names: testin LIM domain protein
• NCBI Official Symbol: TES
• NCBI Official Synonym Symbols: TESS; TESS-2
• NCBI Protein Information: testin
• UniProt Protein Name: Testin
• Protein Family: Tesmin
• UniProt Gene Name: TES
• UniProt Entry Name: TES_HUMAN

Uniprot Description

TES: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. Belongs to the prickle / espinas / testin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 7q31.2

Cellular Component: protein complex; focal adhesion; cytoplasm; plasma membrane; nucleus; cell junction

Molecular Function: zinc ion binding

Biological Process: negative regulation of cell proliferation