Western Blot (WB)
(Western blot analysis of TECR expression in HEK293T (A) whole cell lysates.)
Rabbit TECR Polyclonal Antibody | anti-TECR antibody
Anti-TECR Antibody
Western Blot (WB)
(Western blot analysis of TECR expression in HEK293T (A) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of TECR expression in HEK293T (A) whole cell lysates.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of TECR staining in human liver formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of TECR staining in human liver formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2011]
Uniprot Description
GPSN2: Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids. Defects in TECR are the cause of mental retardation autosomal recessive type 14 (MRT14). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the steroid 5-alpha reductase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.3.1.93; Membrane protein, integral; Oxidoreductase; Membrane protein, multi-pass; Lipid Metabolism - unsaturated fatty acid biosynthesis
Chromosomal Location of Human Ortholog: 19p13.12
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; nucleus
Molecular Function: oxidoreductase activity, acting on the CH-CH group of donors; protein binding
Biological Process: cellular lipid metabolic process; fatty acid elongation; triacylglycerol biosynthetic process; very-long-chain fatty acid biosynthetic process
Disease: Mental Retardation, Autosomal Recessive 14
Research Articles on TECR
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Product Notes
The TECR tecr (Catalog #AAA8243129) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-TECR Antibody reacts with Human, Mouse, Rat, Bovine and may cross-react with other species as described in the data sheet. AAA Biotech's TECR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western Blot: (1/500 - 1/1000); Immunohistochemistry: (1/100 - 1/200). Researchers should empirically determine the suitability of the TECR tecr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TECR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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