Rabbit anti-Human TDRD1 Polyclonal Antibody | anti-TDRD1 antibody

TDRD1, CT (TDRD1, Tudor domain-containing protein 1, Cancer/testis antigen 41.1) (PE)

Cat. Num. AAA6354644

• Gene Names: TDRD1; CT41.1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TDRD1; Polyclonal Antibody; CT (TDRD1; Tudor domain-containing protein 1; Cancer/testis antigen 41.1) (PE); Cancer/testis antigen 41.1; anti-TDRD1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-TDRD1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TDRD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 973-1002 amino acids from the C-terminal region of human TDRD1.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(TDRD1 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the TDRD1 antibody detected the TDRD1 protein (arrow).)

Related Product Information for anti-TDRD1 antibody

This gene is similar to a mouse gene that encodes a tudor domain protein. Alternatively spliced transcript variants have been described but their full length sequences have not been determined.

Product Categories/Family for anti-TDRD1 antibody

Antibodies; Spermatogenesis; Testis Proteins

References

Wu, C., et al. Proteomics 7(11):1775-1785(2007). Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006). Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006). Wang, P.J., et al. Nat. Genet. 27(4):422-426(2001).

NCBI and Uniprot Product Information

• NCBI GI #: 38505161
• NCBI GeneID: 56165
• NCBI Accession #: NP_942090.1
• NCBI GenBank Nucleotide #: NM_198795.1
• UniProt Accession #: Q9BXT4; Q4G0Y8; Q6P518; Q9H7B3; A6NEN3; A6NMN2; B3KVI4; B4E2L5; D3DRC2
• Molecular Weight: 79,170 Da
• NCBI Official Full Name: tudor domain-containing protein 1
• NCBI Official Synonym Full Names: tudor domain containing 1
• NCBI Official Symbol: TDRD1
• NCBI Official Synonym Symbols: CT41.1
• NCBI Protein Information: tudor domain-containing protein 1
• UniProt Protein Name: Tudor domain-containing protein 1
• Protein Family: Tudor domain-containing protein
• UniProt Gene Name: TDRD1
• UniProt Synonym Gene Names: CT41.1
• UniProt Entry Name: TDRD1_HUMAN

NCBI Description

This gene is similar to a mouse gene that encodes a tudor domain protein. Alternatively spliced transcript variants have been described but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

TDRD1: Plays a central role during spermatogenesis by participating in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins. Belongs to the TDRD1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: 10q25.3

Cellular Component: cytoplasm

Molecular Function: metal ion binding; protein binding

Biological Process: DNA methylation during gametogenesis; germ cell development; meiotic cell cycle; multicellular organismal development; RNA-mediated gene silencing; spermatogenesis