Western Blot (WB)
(Western blot analysis of extracts from A375 cells, using TCN2 Antibody. The lane on the left was treated with blocking peptide.)
Rabbit TCN2 Polyclonal Antibody | anti-TCN2 antibody
TCN2 Antibody
Predicted: Pig, Rabbit
Predicted: Pig, Rabbit
Western Blot (WB)
(Western blot analysis of extracts from A375 cells, using TCN2 Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from A375 cells, using TCN2 Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from various samples, using TCN2 Antibody. Lane 1: 293, treated with blocking peptide; Lane 2: 293; Lane 3: Hela cells.)
Western Blot (WB)
(Western blot analysis of extracts from various samples, using TCN2 Antibody. Lane 1: 293, treated with blocking peptide; Lane 2: 293; Lane 3: Hela cells.)
Subunit Structure: Interacts with CD320 (via LDL-receptor class A domains).
Similarity: Belongs to the eukaryotic cobalamin transport proteins family.
NCBI and Uniprot Product Information
Predicted: 48 kDa
NCBI Description
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Uniprot Description
TCN2: Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency). This results in various forms of anemia. Belongs to the eukaryotic cobalamin transport proteins family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: extracellular space; lysosomal lumen; extracellular region; endosome
Molecular Function: metal ion binding; cobalamin binding
Biological Process: vitamin metabolic process; cobalamin metabolic process; cobalamin transport; cobalt ion transport; water-soluble vitamin metabolic process
Disease: Transcobalamin Ii Deficiency
Research Articles on TCN2
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Product Notes
The TCN2 tcn2 (Catalog #AAA9611518) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TCN2 Antibody reacts with Human, Mouse, Rat Predicted: Pig, Rabbit and may cross-react with other species as described in the data sheet. AAA Biotech's TCN2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the TCN2 tcn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TCN2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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