Rabbit anti-Human TCL1A Polyclonal Antibody | anti-TCL1A antibody

TCL1A (T Cell Lymphoma 1A, TCL1) (FITC)

Cat. Num. AAA6440161

• Gene Names: TCL1A; TCL1
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: TCL1A; Polyclonal Antibody; TCL1A (T Cell Lymphoma 1A; TCL1) (FITC); anti-TCL1A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human TCL1A.
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
• Concentration: ~1mg/ml (varies by lot)

• Applicable Applications for anti-TCL1A antibody: Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IHC: 1:50-1:200; WB: 1:500-1:2000; Applications are based on unconjugated antibody.
• Immunogen: Recombinant protein corresponding to human TCL1A.
• Conjugate: FITC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of Ramos cell lysate using TCL1A antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded rat brain using TCL1A antibody at dilution of 1:100 (400x lens).)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded rat lung using TCL1A antibody at dilution of 1:100 (200x lens).)

Product Categories/Family for anti-TCL1A antibody

Antibodies; Cancer Markers

NCBI and Uniprot Product Information

• NCBI GI #: 3024699
• NCBI GeneID: 8115
• UniProt Accession #: P56279; Q6IBK7
• Molecular Weight: 114
• NCBI Official Full Name: T-cell leukemia/lymphoma protein 1A
• NCBI Official Synonym Full Names: T-cell leukemia/lymphoma 1A
• NCBI Official Symbol: TCL1A
• NCBI Official Synonym Symbols: TCL1
• NCBI Protein Information: T-cell leukemia/lymphoma protein 1A; oncogene TCL1; oncogene TCL-1; protein p14 TCL1; T-cell lymphoma-1
• UniProt Protein Name: T-cell leukemia/lymphoma protein 1A
• Protein Family: T-cell leukemia/lymphoma protein
• UniProt Gene Name: TCL1A
• UniProt Synonym Gene Names: TCL1; Oncogene TCL1
• UniProt Entry Name: TCL1A_HUMAN

NCBI Description

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]

Uniprot Description

TCL1A: Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity. Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation. Belongs to the TCL1 family.

Protein type: Oncoprotein; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: endoplasmic reticulum; pronucleus; cell cortex

Molecular Function: protein binding

Biological Process: multicellular organismal development; stem cell maintenance