Rabbit TCF7 Polyclonal Antibody | anti-TCF7 antibody

TCF7 antibody

Cat. Num. AAA9401920

• Gene Names: TCF7; TCF-1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: TCF7; Polyclonal Antibody; TCF7 antibody; TCF-1; anti-TCF7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total TCF7 antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 269

• Applicable Applications for anti-TCF7 antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500 - 1:1000
• Immunogen Type: Peptide
• Immunogen Description: A synthetic peptide of human TCF7.
• Target Name: TCF7
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using TCF7 antibody.)

Related Product Information for anti-TCF7 antibody

The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-TCF7 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 293651582
• NCBI GeneID: 6932
• NCBI Accession #: NP_001128323.2
• NCBI GenBank Nucleotide #: NM_001134851.2
• UniProt Accession #: P36402; Q86WR9; Q9UKI4; B3KSH3
• Molecular Weight: 30,291 Da
• NCBI Official Full Name: transcription factor 7 isoform 3
• NCBI Official Synonym Full Names: transcription factor 7 (T-cell specific, HMG-box)
• NCBI Official Symbol: TCF7
• NCBI Official Synonym Symbols: TCF-1
• NCBI Protein Information: transcription factor 7
• UniProt Protein Name: Transcription factor 7
• Protein Family: Transcription factor
• UniProt Gene Name: TCF7
• UniProt Synonym Gene Names: TCF1; TCF-7; T-cell factor 1; TCF-1
• UniProt Entry Name: TCF7_HUMAN

NCBI Description

The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ CD8+ immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.