Rabbit anti-Human TBX6 Polyclonal Antibody | anti-TBX6 antibody

Rabbit Polyclonal to Human TBX6

Cat. Num. AAA241090

• Gene Names: TBX6; SCDO5
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Protein G Purified
• Synonyms: TBX6; Polyclonal Antibody; Rabbit Polyclonal to Human TBX6; Anti-TBX6 Antibody (aa361-377) IHC-plus; T-box protein 6; T-box 6; DFNB67; Human TBX6; anti-TBX6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Amino acids 361 to 377 of human TBX6
• Purity/Purification: Protein G Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 436

• Applicable Applications for anti-TBX6 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA (1:000 - 1:1000), IHC-P (10 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
• Target Species: Human
• Immunogen Description: Synthetic peptide from human TBX6.
• Immunogen Type: Synthetic peptide
• Immunogen: TBX6 antibody was raised against synthetic peptide from human TBX6.
• Antigen Modification: aa361-377
• Preparation and Storage: Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

Immunohistochemistry (IHC)

(Anti-TBX6 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 18201900
• NCBI GeneID: 6911
• NCBI Accession #: NP_004599.2
• NCBI GenBank Nucleotide #: NM_004608.3
• UniProt Accession #: O95947; Q8TAS4; Q9HA44
• Molecular Weight: 33,197 Da
• NCBI Official Full Name: T-box transcription factor TBX6
• NCBI Official Synonym Full Names: T-box 6
• NCBI Official Symbol: TBX6
• NCBI Official Synonym Symbols: SCDO5
• NCBI Protein Information: T-box transcription factor TBX6; T-box protein 6
• UniProt Protein Name: T-box transcription factor TBX6
• Protein Family: T-box transcription factor
• UniProt Gene Name: TBX6
• UniProt Synonym Gene Names: T-box protein 6
• UniProt Entry Name: TBX6_HUMAN

NCBI Description

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures. [provided by RefSeq, Aug 2008]

Uniprot Description

TBX6: T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: nucleus

Molecular Function: DNA binding; transcription factor activity

Biological Process: negative regulation of neuron maturation; anatomical structure morphogenesis; transcription, DNA-dependent; mesoderm formation; positive regulation of transcription from RNA polymerase II promoter; cell fate specification; mesoderm development; negative regulation of transcription from RNA polymerase II promoter; somite rostral/caudal axis specification

Disease: Deafness, Autosomal Recessive 67