Rabbit anti-Human TBX6 Polyclonal Antibody | anti-TBX6 antibody

TBX6 Antibody

Cat. Num. AAA7049244

• Gene Names: TBX6; SCDO5
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: >95%, Protein G purified
• Synonyms: TBX6; Polyclonal Antibody; TBX6 Antibody; T-box transcription factor TBX6; T-box protein 6; anti-TBX6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 436

• Applicable Applications for anti-TBX6 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1: 20-1: 200
• Immunogen: Recombinant Human T-box transcription factor TBX6 protein (295-436AA)
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugation: Non-conjugated
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-134063
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human placenta tissue using MBS7049244 at dilution of 1:100)

Related Product Information for anti-TBX6 antibody

T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 18201900
• NCBI GeneID: 6911
• NCBI Accession #: NP_004599.2
• NCBI GenBank Nucleotide #: NM_004608.3
• UniProt Accession #: O95947; Q8TAS4; Q9HA44
• Molecular Weight: 33,197 Da
• NCBI Official Full Name: T-box transcription factor TBX6
• NCBI Official Synonym Full Names: T-box 6
• NCBI Official Symbol: TBX6
• NCBI Official Synonym Symbols: SCDO5
• NCBI Protein Information: T-box transcription factor TBX6
• UniProt Protein Name: T-box transcription factor TBX6
• Protein Family: T-box transcription factor
• UniProt Gene Name: TBX6
• UniProt Synonym Gene Names: T-box protein 6
• UniProt Entry Name: TBX6_HUMAN

NCBI Description

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures. [provided by RefSeq, Aug 2008]

Uniprot Description

TBX6: T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 16p11.2

Molecular Function: protein binding

Biological Process: anatomical structure morphogenesis; mesoderm development; negative regulation of transcription from RNA polymerase II promoter

Disease: Spondylocostal Dysostosis 5