Rabbit anti-Human, Mouse TBX21, T-bet Polyclonal Antibody | anti-TBX21, T-bet antibody

TBX21, T-bet Rabbit Polyclonal

Cat. Num. AAA7604771

• Gene Names: TBX21; TBET; T-PET; T-bet; TBLYM
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: TBX21; T-bet; Polyclonal Antibody; T-bet Rabbit Polyclonal; anti-TBX21; T-bet antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 535

• Applicable Applications for anti-TBX21, T-bet antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: T-box 21
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(mouse thymus tissue were subjected to SDS PAGE followed by western blot with MBS7604771 (TBX21,T-bet antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 7019549
• NCBI GeneID: 30009
• NCBI Accession #: NP_037483.1
• NCBI GenBank Nucleotide #: NM_013351.1
• Molecular Weight: 58,328 Da
• NCBI Official Full Name: T-box transcription factor TBX21
• NCBI Official Synonym Full Names: T-box 21
• NCBI Official Symbol: TBX21
• NCBI Official Synonym Symbols: TBET; T-PET; T-bet; TBLYM
• NCBI Protein Information: T-box transcription factor TBX21
• UniProt Protein Name: T-box transcription factor TBX21
• UniProt Gene Name: TBX21
• UniProt Synonym Gene Names: TBET; TBLYM; T-box protein 21
• UniProt Entry Name: TBX21_HUMAN

NCBI Description

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]

Uniprot Description

TBX21: Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs. T-cell specific.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: cell soma; nucleus

Molecular Function: transcription factor activity

Biological Process: multicellular organismal development; positive regulation of isotype switching to IgG isotypes; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to virus; T cell differentiation; transcription, DNA-dependent

Disease: Asthma, Nasal Polyps, And Aspirin Intolerance