Rabbit TBX19 Polyclonal Antibody | anti-TBX19 antibody

TBX19 Polyclonal Antibody

Cat. Num. AAA9130981

• Gene Names: TBX19; TPIT; TBS19; dJ747L4.1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purification
• Synonyms: TBX19; Polyclonal Antibody; TBX19 Polyclonal Antibody; TBS19; TPIT; dJ747L4.1; anti-TBX19 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Sequence Length: 448

• Applicable Applications for anti-TBX19 antibody: Western Blot (WB)
• Application Notes: WB: 1:500 - 1:2000
• Immunogen: Recombinant protein of human TBX19
• Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of 293T cells, using TBX19 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 30s.)

Related Product Information for anti-TBX19 antibody

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure.

Product Categories/Family for anti-TBX19 antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 6226281
• NCBI GeneID: 9095
• UniProt Accession #: O60806; Q52M53
• Molecular Weight: 48kDa
• NCBI Official Full Name: T-box transcription factor TBX19
• NCBI Official Synonym Full Names: T-box 19
• NCBI Official Symbol: TBX19
• NCBI Official Synonym Symbols: TPIT; TBS19; dJ747L4.1
• NCBI Protein Information: T-box transcription factor TBX19
• UniProt Protein Name: T-box transcription factor TBX19
• Protein Family: T-box transcription factor
• UniProt Gene Name: TBX19
• UniProt Synonym Gene Names: TPIT; T-box protein 19

NCBI Description

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure. [provided by RefSeq, Jul 2008]

Uniprot Description

TBX19: Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters. Defects in TBX19 are a cause of ACTH deficiency isolated (IAD). ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure (hypotension). The pituitary hormone ACTH is decreased or absent, and other cortisol and other steroid hormone levels in the blood are abnormally low.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 1q24.2

Biological Process: anatomical structure morphogenesis; regulation of transcription from RNA polymerase II promoter

Disease: Acth Deficiency, Isolated